3.8 Review

Laboratory diagnosis of COVID-19: current status and challenges

Journal

IRANIAN JOURNAL OF MICROBIOLOGY
Volume 13, Issue 1, Pages 1-7

Publisher

UNIV MEDICAL SCIENCES-DANISHGAH-I ULUM-I PIZISHKI-I TIHRAN

Keywords

COVID-19; SiRS-CoV-2; Coronavirus; Diagnosis; COVID-19 nucleic acid testing; Enzyme-linked immunosorbent assay

Categories

Funding

  1. Department of Biotechnology, Govt. of India
  2. Department of Science and Technology, Govt. of India
  3. Department of Health Research, Govt. of India

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The global impact of COVID-19 has been unprecedented, with rapid spread and high numbers of infections and deaths. The key strategy to control the pandemic is early diagnosis and isolation of infected individuals, with various diagnostic methods such as molecular and immunological assays being utilized. This review aims to provide updates on current diagnostic modalities and challenges associated with them in the rapidly evolving landscape of COVID-19 testing.
The magnitude and pace of global affliction caused by Coronavirus Disease-19 (COVID-19) is unprecedented in the recent past. From starting in a busy seafood market in the Chinese city of Wuhan, the virus has spread across the globe in less than a year, infecting over 76 million people and causing death of close to 1.7 million individuals worldwide. As no specific antiviral treatment is currently available, the major strategy in containing the pandemic is focused on early diagnosis and prompt isolation of the infected individuals. Several diagnostic modalities have emerged within a relatively short period, which can be broadly classified into molecular and immunological assays. While the former category is centered around real-time PCR, which is currently considered the gold standard of diagnosis, the latter aims to detect viral antigens or antibodies specific to the viral antigens and is yet to be recommended as a stand-alone diagnostic tool. This review aims to provide an update on the different diagnostic modalities that are currently being used in diagnostic laboratories across the world as well as the upcoming methods and challenges associated with each of them. In a rapidly evolving diagnostic landscape with several testing platforms going through various phases of development and/or regulatory clearance, it is prudent that the clinical community familiarizes itself with the nuances of different testing modalities currently being employed for this condition.

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