Journal
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
Volume 19, Issue 4, Pages 301-312Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/14779072.2021.1902806
Keywords
Coronary artery disease; drug-eluting stent; female patients; gender medicine; percutaneous coronary intervention; personalized medicine; sex; women
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Despite the common belief that coronary artery disease is primarily a male-centric condition, sex-based disparities exist in various aspects, including outcomes after PCI with stent implantation. While new-generation DES have improved clinical outcomes, there is a lack of sex-specific guidelines due to limited participation of women in clinical trials. Improved performances of DES are narrowing the sex gap in PCI outcomes, and ongoing gender initiatives and sex-specific trials aim to address current issues in the field.
Introduction: Despite common perceptions, coronary artery disease (CAD) is not a male-specific condition, and sex-based differences do occur in many aspects, including clinical outcomes after percutaneous coronary intervention (PCI) with stent implantation. New-generation drug-eluting stents (DES) significantly improved post-PCI outcomes. However, no sex-specific guidelines on PCI and the use of DES are available as current evidence was derived from clinical trials enrolling predominantly male patients. Areas covered: This review aims at exploring sex-based disparities in CAD characteristics and manifestations, and comparing PCI outcomes and the efficacy and safety profiles of DES according to sex. In addition, a critical approach to trials' interpretation with an analysis of sources of bias is provided to inform future research and clinical practice. Expert opinion: Sex gap in clinical outcomes after PCI with DES implantation is narrowing due to improved performances of new-generation DES. However, scientific research and biomedical engineering are striving to optimize DES profiles and generate new iterations of devices. At the same time, gender initiatives and sex-specific trials are accruing to overcome current issues in the field. Advances in these areas will foster improvements in early and long-term clinical outcomes of both women and men.
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