Journal
HETEROCYCLES
Volume 102, Issue 2, Pages 291-317Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-20-14354
Keywords
-
Categories
Ask authors/readers for more resources
This study synthesized 1-(2-hydroxy-4-methylphenyl)-3-phenylpropane-1,3-dione in a quantitative yield from the reaction of ethyl benzoylacetate and m-cresol using a microwave without solvents. Various derivatives were then synthesized through different chemical reactions, and these compounds exhibited varying degrees of antimicrobial activity.
This study aims to synthesis of 1-(2-hydroxy-4-methylphenyl)-3-phenylpropane-1,3-dione 3 in a quantitative yield from the reaction of ethyl benzoylacetate and m-cresol using a microwave in the absence of solvents. Phenylpropane-1,3-dione derivative 3 was used as the key synthetic intermediate for the synthesis of many derivatives in this study. A new pyrazole 12, pyrimidine 15, thiophene 37, 4H-pyrane 51 and pyridine derivatives 8, 28, 34, 41 and 46 were synthesized through different chemical reactions. The structures of the newly synthesized compounds were confirmed based on analytical and spectral data. The compounds were evaluated for both their in vitro antibacterial and antifungal activities. The compounds showed varying degree of antimicrobial activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available