SYNTHESIS AND BIOLOGICAL STUDIES OF SOME NEW PYRAZOLE, DIHYDROPYRIDINETHIONE, PYRIMIDINE, THIOPHENE AND 4H-PYRAN DERIVATIVES

This study aims to synthesis of 1-(2-hydroxy-4-methylphenyl)-3-phenylpropane-1,3-dione 3 in a quantitative yield from the reaction of ethyl benzoylacetate and m-cresol using a microwave in the absence of solvents. Phenylpropane-1,3-dione derivative 3 was used as the key synthetic intermediate for the synthesis of many derivatives in this study. A new pyrazole 12, pyrimidine 15, thiophene 37, 4H-pyrane 51 and pyridine derivatives 8, 28, 34, 41 and 46 were synthesized through different chemical reactions. The structures of the newly synthesized compounds were confirmed based on analytical and spectral data. The compounds were evaluated for both their in vitro antibacterial and antifungal activities. The compounds showed varying degree of antimicrobial activity.

Automated summary

This study synthesized 1-(2-hydroxy-4-methylphenyl)-3-phenylpropane-1,3-dione in a quantitative yield from the reaction of ethyl benzoylacetate and m-cresol using a microwave without solvents. Various derivatives were then synthesized through different chemical reactions, and these compounds exhibited varying degrees of antimicrobial activity.