Journal
CHEMICAL SOCIETY REVIEWS
Volume 50, Issue 23, Pages 13410-13440Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cs00632k
Keywords
-
Categories
Funding
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/P017711/1]
- BBSRC [BB/S018794/1]
- Leverhulme Trust [RPG-2018-251]
- BBSRC [BB/S018794/1, BB/P017711/1] Funding Source: UKRI
Ask authors/readers for more resources
The self-assembly of inorganic nanoparticles into larger structures allows for the fabrication of novel materials with collective properties; recently developed methods for controlling nanoparticle organization have enabled the fabrication of new materials; DNA modifications and molecular intercalators have been utilized as tools for manipulating DNA-nanoparticle structures.
The self-assembly of inorganic nanoparticles to larger structures is of great research interest as it allows the fabrication of novel materials with collective properties correlated to the nanoparticles' individual characteristics. Recently developed methods for controlling nanoparticle organisation have enabled the fabrication of a range of new materials. Amongst these, the assembly of nanoparticles using DNA has attracted significant attention due to the highly selective recognition between complementary DNA strands, DNA nanostructure versatility, and ease of DNA chemical modification. In this review we discuss the application of various chemical DNA modifications and molecular intercalators as tools for the manipulation of DNA-nanoparticle structures. In detail, we discuss how DNA modifications and small molecule intercalators have been employed in the chemical and photochemical DNA ligation in nanostructures; DNA rotaxanes and catenanes associated with reconfigurable nanoparticle assemblies; and DNA backbone modifications including locked nucleic acids, peptide nucleic acids and borane nucleic acids, which affect the stability of nanostructures in complex environments. We conclude by highlighting the importance of maximising the synergy between the communities of DNA chemistry and nanoparticle self-assembly with the aim to enrich the library of tools available for the manipulation of nanostructures.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available