Journal
BIOMICROFLUIDICS
Volume 15, Issue 3, Pages -Publisher
AIP Publishing
DOI: 10.1063/5.0052314
Keywords
-
Categories
Funding
- NIGMS NIH HHS [T32 GM066706] Funding Source: Medline
Ask authors/readers for more resources
The study presents a new technology for simple, fast, and robust assembly of customizable and scalable microfluidic devices with minimal facilities. This technology is broadly applicable to research that needs or could be enhanced by microfluidics.
Microfluidic technology has tremendously facilitated the development of in vitro cell cultures and studies. Conventionally, microfluidic devices are fabricated with extensive facilities by well-trained researchers, which hinder the widespread adoption of the technology for broader applications. Enlightened by the fact that low-cost microbore tubing is a natural microfluidic channel, we developed a series of adaptors in a toolkit that can twine, connect, organize, and configure the tubing to produce functional microfluidic units. Three subsets of the toolkit were thoroughly developed: the tubing and scoring tools, the flow adaptors, and the 3D cell culture suite. To demonstrate the usefulness and versatility of the toolkit, we assembled a microfluidic device and successfully applied it for 3D macrophage cultures, flow-based stimulation, and automated near real-time quantitation with new knowledge generated. Overall, we present a new technology that allows simple, fast, and robust assembly of customizable and scalable microfluidic devices with minimal facilities, which is broadly applicable to research that needs or could be enhanced by microfluidics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available