Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 97, Pages 13138-13141Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc05099k
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An enantioselective tandem Friedel-Crafts alkylation/annulation of indoles with diazoacetoacetate enones was achieved in one pot using a Rh-II/Sc-III dual-metallic catalyst system. A series of dihydrocarbazoles were obtained with moderate yields and good to excellent ee values. Control experiments confirmed the critical role of Sc-III in both alkylation and annulation processes.
An enantioselective tandem Friedel-Crafts alkylation/annulation of indoles with diazoacetoacetate enones is realized in one pot. A series of dihydrocarbazoles were obtained in moderate yields with good to excellent ee values by using a Rh-II/Sc-III dual-metallic catalyst system. Control experiments revealed that Sc-III is critical to both the alkylation and annulation.
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