Journal
ANALYST
Volume 146, Issue 24, Pages 7528-7536Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1an01762d
Keywords
-
Categories
Funding
- Talent Program -Outstanding Youth Science Project, Liaoning [XLYC1807199]
- Scientific Research Fund General Project of the Liaoning Province Department of Education [LJKZ0277]
- Distinguished Professor Program of Liaoning [XLYC1802074]
- Seeding Raising Project of Young Scientific and Technological Talents of Liaoning Provincial Department of Education [2019LNQN03, 2019LNJC18]
- Graduate education reform and science AMP
- technology innovation and entrepreneurship project of the University of Science and Technology Liaoning [LKDYC202011]
Ask authors/readers for more resources
A phenothiazine-based fluorescent probe (PR) has been developed for the selective detection of hydrogen sulfide (H2S) in biosystems and monitoring H2S produced in the food spoilage process. PR showed high selectivity and sensitivity, low cytotoxicity, and reliability at physiological pH. The probe was successfully applied for the visualization of exogenous and endogenous H2S in living cells and live animals, as well as for monitoring H2S production in an inflammation model.
In this work, a phenothiazine-based fluorescent probe (PR) has been developed for the selective detection of hydrogen sulfide (H2S) in biosystems and monitoring H2S produced in the food spoilage process. The nucleophilic attack of H2S on the C=C double bond of PR via a Michael addition interdicted the ICT process to trigger 34-fold enhancement of the fluorescence emission. PR featured high selectivity and sensitivity (18 mu M), low cytotoxicity and reliability at physiological pH. Naked-eye monitoring of H2S produced in the food spoilage process using PR was successfully accomplished. The preliminary fluorescence imaging studies showed that PR is suitable for the visualization of exogenous and endogenous H2S in living cells and live animals. Moreover, PR has been successfully applied to the visualization of H2S generation in an inflammation model. The results indicated that PR is an effective tool to monitor H2S production in the fields of biomedicine and food safety.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available