Journal
ANALYST
Volume 146, Issue 24, Pages 7374-7378Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1an01809d
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Funding
- National Natural Science Foundation of China [21908032]
- Natural Science Foundation Program of Guangxi Province [2018GXNSFBA281194]
- Science and Technology Planning Project of Guangxi [2020AC19096]
- Foundation of Guangxi Educational Committee [20190KY0321]
- Project of Guangxi Key Laboratory of Chinese Medicine Foundation Research [19-050-45-02]
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This study introduces a novel H2S donor, HSD560, which releases H2S triggered by cysteine, accompanied by enhanced green fluorescence for tracking H2S release in cells. The H2S release from HSD560 undergoes a non-enzymatic native chemical ligation process, accurately matching activated fluorescence and localizing H2S in zebrafish.
A hydrogen sulfide (H2S) donor is a fundamental molecular tool used as an exogenous source in biological studies and therapies. However, finding a controllable and visual fluorescent H2S donor is difficult. We report a new H2S donor, HSD560, the H2S release of which is triggered by cysteine. Importantly, the H2S generation is accompanied with enhanced green fluorescence, which could be utilized to track H2S release in cells using microscopy. H2S release from HSD560 undergoes a non-enzymatic native chemical ligation (NCL) process, which provides an accurate match with activated fluorescence and localization of H2S in zebrafish.
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