MicroRNA-4732 is downregulated in non-small cell lung cancer and inhibits tumor cell proliferation, migration, and invasion

Background:: Non-small cell lung cancer (NSCLC) is the leading cause of cancer death with increasing morbidity and mortality. MicroRNA-4732-5p (miR-4732-5p) has been reported to be dysregulated in various cancers and identified as a tumor suppressor. This study aims to explore the expression and role of miR-4732-5p in NSCLC. Methods:: Reverse transcription-quantitative polymerase chain reaction (qRT-PCR) assay was employed to detect the expression of miR-4732-5p in NSCLC. With the help of Kaplan-Meier survival and Cox regression, the prognostic significance of miR-4732-5p was investigated. Meanwhile, the effects of miR-4732-5p on cell proliferation, migration, and invasion were also studied. Results:: The expression of miR-4732-5p decreased in NSCLC tissues and cells. The downregulation of miR-4732-5p was closely associated with lymph node metastasis, TNM stage, and poor prognosis. Multivariate Cox regression analysis results showed that miR-4732-5p was an independent prognosis factor for NSCLC. In addition, the overexpression of miR-4732-5p inhibited the proliferation, migration, and invasion of NSCLC cells through modulating TSPAN13. Conclusions:: These data showed that miR-4732-5p might be involved in the development of NSCLC, which can act as an independent prognostic biomarker and therapeutic target. (C) 2021 SPLF and Elsevier Masson SAS. All rights reserved.

Automated summary

miR-4732-5p expression is decreased in NSCLC and is associated with patient prognosis, potentially inhibiting proliferation, migration, and invasion of NSCLC cells by modulating TSPAN13.