Concise synthesis and applications of enantiopure spirobiphenoxasilin-diol and its related chiral ligands

The development of chiral architectures for chiral ligand and catalyst discovery is essential for asymmetric catalysis. Herein, we report the concise synthesis of a Si-centered spirocyclic skeleton, spirobiphenoxasilin-diol (SPOSiOL), and its derived chiral ligands. Using the chemical resolution method, the optical SPOSiOL could be obtained in high yield on a gram scale. Preliminary studies indicated that this ligand scaffold has great potential in transition metal-catalyzed asymmetric reactions. This finding further highlights that the Si-centered spirocyclic scaffolds are of great value in asymmetric catalysis.

Automated summary

The synthesis of a Si-centered spirocyclic skeleton, SPOSiOL, and its derived chiral ligands were reported in this study, showcasing their potential in transition metal-catalyzed asymmetric reactions. This finding emphasizes the value of Si-centered spirocyclic scaffolds in asymmetric catalysis.