Journal
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
Volume 5, Issue 8, Pages -Publisher
ELSEVIER
DOI: 10.1002/rth2.12632
Keywords
biomarkers; cardiovascular diseases; D-dimer; race; thrombo-inflammation
Categories
Funding
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institute on Aging (NIA), National Institutes of Health, Department of Health and Human Service
- National Heart, Lung, and Blood Institute [K08HL096841]
- [U01 NS041588]
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The study revealed that Black individuals have different correlations between D-dimer and thrombo-inflammatory biomarkers compared to White individuals, suggesting a potential link between D-dimer and racial disparities in cardiovascular diseases and venous thromboembolism. This indicates that D-dimer may serve as a marker of amplified thrombo-inflammatory response in Black people. Further investigation is needed to better understand the factors contributing to higher D-dimer levels in the general population.
Background: Higher D-dimer is a risk factor for cardiovascular diseases and venous thromboembolism. In the general population, D-dimer and other thrombo-inflammatory biomarkers are higher among Black individuals, who also have higher risk of these conditions compared to White people. Objective: To assess whether Black individuals have an exaggerated correlation between D-dimer and thrombo-inflammatory biomarkers characteristic of cardiovascular diseases. Methods: Linear regression was used to assess correlations of 11 thrombo-inflammatory biomarkers with D-dimer in a cross-sectional study of 1068 participants of the biracial Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Results: Adverse levels of most biomarkers, especially fibrinogen, factor VIII, C-reactive protein, N-terminal pro-B-type natriuretic peptide, and interleukin (IL)-6, were associated with higher D-dimer. Several associations with D-dimer differed significantly by race. For example, the association of factor VIII with D-dimer was more than twice as large in Black compared to White participants. Specifically, D-dimer was 26% higher per standard deviation (SD) higher factor VIII in Black adults and was only 11% higher per SD higher factor VIII in White adults. In Black but not White adults, higher IL-10 and soluble CD14 were associated with higher D-dimer. Conclusions: Findings suggest that D-dimer might relate to Black/White differences in cardiovascular diseases and venous thromboembolism because it is a marker of amplified thrombo-inflammatory response in Black people. Better understanding of contributors to higher D-dimer in the general population is needed.
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