Treatment of refractory and super-refractory status epilepticus with brivaracetam: A cohort study from two German university hospitals

Purpose: We aimed to ascertain the possible use of brivaracetam (BRV) as an option for treatment of status epilepticus (SE). Methods: A review of medical records was carried out to detect BRV administration in SE patients treated in Frankfurt and Greifswald during the period February 2016 to January 2017. The primary outcome question concerned SE resolution after BRV initiation. Results: During that period, BRV was started with eleven adult patients with SE. Five of these were female, and the median age was 64 (interquartile range [IQR] 21 years). The median SE duration before BRV initiation was 5 days (IQR 9 days); the median number of previous anticonvulsants used was 4 (IQR 5). Initial BRV doses ranged between 50 mg and 400 mg (median 100 mg), titrated to a daily dose of 100 to 400 mg (median 200 mg). There was a cessation of SE in the first 24 h of BRV in three patients (27%). While taldng BRV, no serious side effects were seen. Conclusion: Based on these cases and previous data from animal experiments, BRV may prove useful in SE treatment, and trials would be warranted to examine BRV's efficacy in treating SE and how this efficacy might be influenced by co-administration with levetiracetam. (C) 2017 Elsevier Inc. All rights reserved.