3-(Bromoacetyl)coumarins: unraveling their synthesis, chemistry, and applications

This review emphasizes recent developments in synthetic routes of 3-(bromoacetyl)coumarin derivatives. Also, chemical reactions of 3-(bromoacetyl)coumarins as versatile building blocks in the preparation of critical polyfunctionalized heterocyclic systems and other industrially significant scaffolds are described. Recent advances of 3-(bromoacetyl)coumarins as attractive starting points towards a wide scale of five and six-membered heterocyclic systems such as thiophenes, imidazoles, pyrazoles, thiazoles, triazoles, pyrans, pyridines, thiadiazins as well as fused heterocyclic systems have been reported. Additionally, this review covers a wide range of analytical chemistry, fluorescent sensors, and biological applications of these moieties, covering the literature till May 2021.

Automated summary

This review emphasizes recent advances in synthetic routes of 3-(bromoacetyl)coumarin derivatives and their versatility as building blocks in the preparation of polyfunctionalized heterocyclic systems and industrially significant scaffolds. It also highlights the attractiveness of 3-(bromoacetyl)coumarins as starting points for a wide range of five and six-membered heterocyclic systems. Additionally, the review covers the wide-ranging applications of these moieties in analytical chemistry, fluorescent sensors, and biological settings.