Journal
RESPIRATORY RESEARCH
Volume 22, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12931-021-01899-2
Keywords
Alveoli; Dimension trap; Disector; Histology; Lung; Microscopy; Morphometry; Reference trap; Sampling; Stereology
Categories
Funding
- German Research Federation (DFG) [SFB 1449/B01]
- Berlin University Alliance (BUA)
- Else-Kroner-Fresenius-Stiftung [2019_A77]
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This primer highlights the use of stereology for quantitative assessment of lung micro-structure and emphasizes its contribution to improving the quality of laboratory work and good scientific practice.
The intention of this short primer is to raise your appetite for proper quantitative assessment of lung micro-structure. The method of choice for obtaining such data is stereology. Rooted in stochastic geometry, stereology provides simple and efficient tools to obtain quantitative three-dimensional information based on measurements on nearly two-dimensional microscopic sections. In this primer, the basic concepts of stereology and its application to the lung are introduced step by step along the workflow of a stereological study. The integration of stereology in your laboratory work will help to improve its quality. In a broader context, stereology may also be seen as a contribution to good scientific practice.
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