Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 19, Issue 48, Pages 10530-10548Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob01906f
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Funding
- Open Project Program of the Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province [ARRLKF19-07]
- Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department [10Y202106]
- Chengdu University High-level Talent Program [2081920059]
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2H-chromenes, as an important type of oxygen heterocycles, are widely found in natural products, pharmaceutical agents, and biologically relevant molecules. The synthesis of such compounds mainly involves benzopyran ring formation and late-stage functionalization of the parent 2H-chromenes.
As one type of chromene, 2H-chromenes represent important oxygen heterocycles, which not only widely exist in natural products, pharmaceutical agents and biologically relevant molecules, but have also been used broadly in materials science and organic synthesis. Two major synthetic strategies have been developed towards such compounds. This review mainly focuses on the recent advances in this field, including benzopyran ring formation involving cyclization reactions and the late-stage functionalization of the parent 2H-chromenes.
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