Journal
AGING AND DISEASE
Volume -, Issue -, Pages -Publisher
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2021.1122
Keywords
osteoarthritis; chondrocytes; ion channel; cell volume regulation
Categories
Funding
- National Natural Science Foundation of China [81800785, 81972085]
- Natural Science Foundation of Guangdong Province [2018A 0303100027, 2021A1515010706]
- Guangdong Provincial Key Clinical Discipline-Orthopedics [2000005]
- Sanming Project of Shenzhen Health and Family Planning Commission [SZSM201612086]
- Shenzhen Science and Technology Planning [JCYJ20180228163401333, JCYJ20190806170612680]
- Shenzhen Key Medical Discipline Construction Fund [SZXK025]
- Discipline Construction Capacity Improvement project of Shenzhen Municipal Health Commission [SZXJ2018065]
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This review focuses on the important role of volume control-related ion channels in cartilage matrix remodeling and summarizes current views. Additionally, the potential mechanism of the volume-sensitive anion channel LRRC8A in the early occurrence of osteoarthritis is discussed.
Degenerative joint diseases of the hips and knees are common and are accompanied by severe pain and movement disorders. At the microscopic level, the main characteristics of osteoarthritis are the continuous destruction and degeneration of cartilage, increased cartilage extracellular matrix catabolism, decreased anabolism, increased synovial fluid, and decreased osmotic pressure. Cell volume stability is mainly regulated by ion channels, many of which are expressed in chondrocytes. These ion channels are closely related to pain regulation, volume regulation, the inflammatory response, cell proliferation, apoptosis, and cell differentiation. In this review, we focus on the important role of volume control-related ion channels in cartilage matrix remodeling and summarize current views. In addition, the potential mechanism of the volume-sensitive anion channel LRRC8A in the early occurrence of osteoarthritis is discussed.
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