Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 50, Issue -, Pages 151-158Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2017.02.006
Keywords
PBDE-209; Pregnancy; Autophagy; Hippocampus
Funding
- National Natural Science Foundation [81370775, 81571518, 81302399, 81671533]
- Guangdong Province Natural Science Foundation Postdoctoral Project [S2013040013853]
- National Natural Science Foundation for Youth [81402652]
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This study is to investigate the neurotoxicity of PBDE-209 during pregnancy through autophagy and apoptosis in the fetal hippocampus neuron. The autophagy protein levels of LC3-II and Berlin-1 were significantly higher in hippocampus tissue and neuron, while P62 protein were lower. Apoptosis protein Cleaved Caspase-3 and Cleaved PARP was significantly higher in PBDE dose groups and BCL-2 levels in high PBDE dose groups were significantly lower. During the Morris water maze task, the escape latency times of high PBDE dose groups were significantly longer. PBDE-209-induced autophagy leads to neurons death and inhibition of autophagy reduce PBDE-209-induced apoptotic cell death. These results suggest that exposure of the PBDE-209 during pregnancy increases hippocampal autophagy, decrease neuron viability, and it partly effect apoptosis induced by PBDE-209. All that may contribute to the decline of learning and memory ability in the offspring. (C) 2017 Elsevier B.V. All rights reserved.
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