Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 53, Issue -, Pages 111-120Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2017.05.005
Keywords
Acetaminophen; Hematology; Oxidative stress; Histopathology; HPG-axis
Funding
- CAPES (Coordination for the Improvement of Higher Education Personnel)
- CNPq (Brazilian Agency for Science and Technology)
- INCT-TA/CNPq
Ask authors/readers for more resources
Paracetamol is one of the most widely sold non-prescription drugs. This study aimed to evaluate the effects of the paracetamol on reproductive, biochemical, genetic, histopathological and hematogical biomarkers by water-borne exposure. Male fish of Rhamdia quelen were exposed to environmental concentrations of paracetamol (0, 0.25, 2.5 mu g/L) in a semi-static bioassay for 21 days. Hemoglobin and hematocrit were reduced upon exposure to 0.25 mu g/L of paracetamol. Leukocytes and thrombocytes increased after paracetamol exposure. Paracetamol reduced testosterone levels in all exposed groups and increased estradiol levels at higher concentration. Serotonin and dopamine levels increased at exposure to 0,25 mu g/L. Paracetamol also caused protein carbonyls and increased SOD activity in fish exposed to 2.5 mu g/L and in addition led to an inhibition of EROD and GST activities in both concentrations. Hepatic genotoxicity occurred at the 0.25 mu g/L concentration. Hepatic tissues of exposed fish showed mild blood congestion and leucocytes infiltration. The results showed that paracetamol disrupted the hypothalamic-pituitary-gonadal axis, changed hematological parameters and caused hepatotoxicity in Rhamdia quelen. The findings suggest that this drug merits attention relative to its potential endocrine disrupter effect and hepatotoxicity, even at concentrations found in the aquatic environment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available