Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 55, Issue -, Pages 81-86Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2017.08.014
Keywords
Long non-coding RNA; Leukemia; Classification tool; Biomarkers
Funding
- National Natural Science Foundation of China [81273116]
- Science Foundation of Guangdong Medical University [M2013004]
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Long non-coding RNAs (LncRNAs) are a category of non-coding RNAs (ncRNAs) with a length of 200 nt-100 kb lacking a significant open reading frame. The study of lncRNAs is a newly established field, due in part to their capability to act as the novel biomarkers in disease. A growing body of research shows that lncRNAs may not only useful as biomarkers for the diagnosis and clinical typing and prognosis of cancers, but also as potential targets for novel therapies. Differential expression of lncRNAs has been found in leukemia in the last two years, however, the majority of the lncRNAs described here are transcripts of unknown function and their role in leukemogenesis is still unclear. Here, we summarize the lncRNAs associated with leukemia in order to find a potential classification tool for leukemia, and a new field of research is being explored.
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