Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 54, Issue -, Pages 155-161Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2017.06.015
Keywords
Electromagnetic pulse; Offspring; Sex ratio; Sex hormones
Funding
- National Program on Key Basic Research Project [2011CB503704]
- National Natural Science Foundation of China [51277175, 81072272]
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Public concern is growing about the exposure to electromagnetic fields (EMF) and its effect on male reproductive health. Detrimental effect of EMF exposure on sex hormones, reproductive performance and sex-ratio was reported. The present study was designed to clarify whether paternal exposure to electromagnetic pulse (EMP) affects offspring sex ratio in mice. 50 male BALB/c mice aged 5-6 weeks were exposed to EMP daily for 2 weeks before mated with non-exposed females at 0d, 7d, 14d, 21d and 28d after exposure. Sex hormones including total testosterone, LH, FSH, and GnRH were detected using radioimmunoassay. The sex ratio was examined by PCR and agarose gel electrophoresis. The results of DO, D21 and D28 showed significant increases compared with sham-exposed groups. The serum testosterone increased significantly in DO, D14, D21, and D28 compared with sham-exposed groups (p < 0.05). Overall, this study suggested that EMP exposure may lead to the disturbance of reproductive hormone levels and affect the offspring sex ratio.
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