Journal
AGING AND DISEASE
Volume -, Issue -, Pages -Publisher
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2021.1116
Keywords
acetylation; HDAC3; HDAC3 inhibitors; atherosclerosis; cardiovascular diseases
Categories
Funding
- Natural Science Foundation of China [82170485]
- Natural Science Foundation of Hunan Province, China [2019JJ40249, 2018JJ3455]
- Outstanding Young Aid Program for Education Department of Hunan Province, China [18B274]
- Key Project of Hunan Provincial Department of Education [20A427]
- University-Industry Cooperation Education Project of Education Department [202002138007]
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Atherosclerosis, the main pathological basis of cardiovascular diseases, involves plaque formation in blood vessels and HDAC3 has been found to play critical roles in regulating vascular function, cell migration, foam cell formation, and more in the disease process.
Atherosclerosis, the pathological basis of most cardiovascular disease, is characterized by plaque formation in the intima. Secondary lesions include intraplaque hemorrhage, plaque rupture, and local thrombosis. Vascular endothelial function impairment and smooth muscle cell migration lead to vascular dysfunction, which is conducive to the formation of macrophage-derived foam cells and aggravates inflammatory response and lipid accumulation that cause atherosclerosis. Histone deacetylase (HDAC) is an epigenetic modifying enzyme closely related to chromatin structure and gene transcriptional regulation. Emerging studies have demonstrated that the Class I member HDAC3 of the HDAC super family has cell specific functions in atherosclerosis, including 1) maintenance of endothelial integrity and functions, 2) regulation of vascular smooth muscle cell proliferation and migration, 3) modulation of macrophage phenotype, and 4) influence on foam cell formation. Although several studies have shown that HDAC3 may be a promising therapeutic target, only a few HDAC3-selective inhibitors have been thoroughly researched and reported. Here, we specifically summarize the impact of HDAC3 and its inhibitors on vascular function, inflammation, lipid accumulation, and plaque stability in the development of atherosclerosis with the hopes of opening up new opportunities for the treatment of cardiovascular diseases.
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