Related references
Note: Only part of the references are listed.Membrane protein biogenesis at the ER: the highways and byways
Sarah O'Keefe et al.
FEBS JOURNAL (2022)
The mechanisms of integral membrane protein biogenesis
Ramanujan S. Hegde et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)
An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum
Sarah O'Keefe et al.
COMMUNICATIONS BIOLOGY (2021)
Architecture of the active post-translational Sec translocon
Tsai-Hsuan Weng et al.
EMBO JOURNAL (2021)
Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62
Samuel Itskanov et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)
Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily
Melanie A. McDowell et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)
Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage
A. Manuel Liaci et al.
MOLECULAR CELL (2021)
Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle
Ahmad Jomaa et al.
CELL REPORTS (2021)
Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import
Stefan Schorr et al.
FEBS JOURNAL (2020)
A clearer picture of the ER translocon complex
Max Gemmer et al.
JOURNAL OF CELL SCIENCE (2020)
Structural basis for membrane insertion by the human ER membrane protein complex
Tino Pleiner et al.
SCIENCE (2020)
The architecture of EMC reveals a path for membrane protein insertion
John P. O'Donnell et al.
ELIFE (2020)
Double the Fun, Double the Trouble: Paralogs and Homologs Functioning in the Endoplasmic Reticulum
Emma J. Fenech et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89 (2020)
Prion Protein Translocation Mechanism Revealed by Pulling Force Studies
Theresa Kriegler et al.
JOURNAL OF MOLECULAR BIOLOGY (2020)
Structure of the ER membrane complex, a transmembrane-domain insertase
Lin Bai et al.
NATURE (2020)
Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex
Melanie A. McDowell et al.
MOLECULAR CELL (2020)
Delayed by Design: Role of Suboptimal Signal Peptidase Processing of Viral Structural Protein Precursors in Flaviviridae Virus Assembly
Nabeel Alzahrani et al.
VIRUSES-BASEL (2020)
An ER translocon for multi-pass membrane protein biogenesis
Philip T. McGilvray et al.
ELIFE (2020)
Translocon-Associated Protein Complex (TRAP) is Crucial for Co-Translational Translocation of Pre-Proinsulin
T. Kriegler et al.
JOURNAL OF MOLECULAR BIOLOGY (2020)
A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex
Hao-Hsuan Hsieh et al.
NATURE COMMUNICATIONS (2020)
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients
Lakshmi E. Miller-Vedam et al.
ELIFE (2020)
Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex
Xudong Wu et al.
SCIENCE (2020)
Membrane Protein Integration and Topogenesis at the ER
Martin Spiess et al.
PROTEIN JOURNAL (2019)
Versatility of Preprotein Transfer from the Cytosol to Mitochondria
Thomas Becker et al.
TRENDS IN CELL BIOLOGY (2019)
The Ways of Tails: the GET Pathway and more
Nica Borgese et al.
PROTEIN JOURNAL (2019)
The molecular mechanism of cotranslational membrane protein recognition and targeting by SecA
Shuai Wang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)
Structure of the post-translational protein translocation machinery of the ER membrane
Xudong Wu et al.
NATURE (2019)
Structure of the posttranslational Sec protein-translocation channel complex from yeast
Samuel Itskanov et al.
SCIENCE (2019)
Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca2+ Leakage from the Endoplasmic Reticulum
Igor Gamayun et al.
CELL CHEMICAL BIOLOGY (2019)
The ER membrane protein complex is a transmembrane domain insertase
Alina Guna et al.
SCIENCE (2018)
Hsp70 at the membrane: driving protein translocation
Elizabeth A. Craig
BMC BIOLOGY (2018)
Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones
Roman Kityk et al.
MOLECULAR CELL (2018)
Sequential activation of human signal recognition particle by the ribosome and signal sequence drives efficient protein targeting
Jae Ho Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Structure of a prehandover mammalian ribosomal SRP.SRP receptor targeting complex
Kan Kobayashi et al.
SCIENCE (2018)
Defining the physiological role of SRP in protein-targeting efficiency and specificity
Elizabeth A. Costa et al.
SCIENCE (2018)
Structure of the yeast oligosaccharyltransferase complex gives insight into eukaryotic N-glycosylation
Rebekka Wild et al.
SCIENCE (2018)
Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum
Katharina Braunger et al.
SCIENCE (2018)
Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier
Sarah Hassdenteufel et al.
CELL REPORTS (2018)
Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import
Duy Nguyen et al.
NATURE COMMUNICATIONS (2018)
Forces on Nascent Polypeptides during Membrane Insertion and Translocation via the Sec Translocon
Michiel J. M. Niesen et al.
BIOPHYSICAL JOURNAL (2018)
EMC Is Required to Initiate Accurate Membrane Protein Topogenesis
Patrick J. Chitwood et al.
CELL (2018)
Measuring Endoplasmic Reticulum Signal Sequences Translocation Efficiency Using the Xbp1 Arrest Peptide
Theresa Kriegler et al.
CELL CHEMICAL BIOLOGY (2018)
hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells
Sarah Hassdenteufel et al.
FEBS LETTERS (2017)
Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins
Arati Tripathi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins
Joseph Casson et al.
JOURNAL OF CELL SCIENCE (2017)
Targeting and translocation of proteins to the endoplasmic reticulum at a glance
Naama Aviram et al.
JOURNAL OF CELL SCIENCE (2017)
How Do J-Proteins Get Hsp70 to Do So Many Different Things?
Elizabeth A. Craig et al.
TRENDS IN BIOCHEMICAL SCIENCES (2017)
Dissecting the molecular organization of the translocon-associated protein complex
Stefan Pfeffer et al.
NATURE COMMUNICATIONS (2017)
Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome
Ahmad Jomaa et al.
NATURE COMMUNICATIONS (2017)
Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide
Erik Lee Snapp et al.
ELIFE (2017)
The signal recognition particle contacts uL23 and scans substrate translation inside the ribosomal tunnel
Kaert Denks et al.
NATURE MICROBIOLOGY (2017)
Structure of the Sec61 channel opened by a signal sequence
Rebecca M. Voorhees et al.
SCIENCE (2016)
Organization of the native ribosome-translocon complex at the mammalian endoplasmic reticulum membrane
Stefan Pfeffer et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2016)
The SND proteins constitute an alternative targeting route to the endoplasmic reticulum
Naama Aviram et al.
NATURE (2016)
Cotranslational signal-independent SRP preloading during membrane targeting
Justin W. Chartron et al.
NATURE (2016)
Global profiling of SRP interaction with nascent polypeptides
Daniela Schibich et al.
NATURE (2016)
Crystal structure of a substrate-engaged SecY protein-translocation channel
Long Li et al.
NATURE (2016)
Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon
Ahmad Jomaa et al.
NATURE COMMUNICATIONS (2016)
Competitive Inhibition of the Endoplasmic Reticulum Signal Peptidase by Non-cleavable Mutant Preprotein Cargos
Jingqiu Cui et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
The Code for Directing Proteins for Trans location across ER Membrane: SRP Cotranslationally Recognizes Specific Features of a Signal Sequence
IngMarie Nilsson et al.
JOURNAL OF MOLECULAR BIOLOGY (2015)
Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events
Brian J. Conti et al.
MOLECULAR CELL (2015)
The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum
Martin Gamerdinger et al.
SCIENCE (2015)
Tissue-based map of the human proteome
Mathias Uhlen et al.
SCIENCE (2015)
Structure of the native Sec61 protein-conducting channel
Stefan Pfeffer et al.
NATURE COMMUNICATIONS (2015)
Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation
Bhalchandra Jadhav et al.
NATURE COMMUNICATIONS (2015)
Structures of the scanning and engaged states of the mammalian SRP-ribosome complex
Rebecca M. Voorhees et al.
ELIFE (2015)
Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution
Rebecca M. Voorhees et al.
CELL (2014)
Inefficient SRP Interaction with a Nascent Chain Triggers a mRNA Quality Control Pathway
Andrey L. Karamyshev et al.
CELL (2014)
Embracing the void-how much do we really know about targeting and translocation to the endoplasmic reticulum?
Naama Aviram et al.
CURRENT OPINION IN CELL BIOLOGY (2014)
Signal Recognition Particle-ribosome Binding Is Sensitive to Nascent Chain Length
Thomas R. Noriega et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion
Marko Gogala et al.
NATURE (2014)
Structure of the mammalian oligosaccharyltransferase complex in the native ER protein translocon
Stefan Pfeffer et al.
NATURE COMMUNICATIONS (2014)
TRAP assists membrane protein topogenesis at the mammalian ER membrane
Nicole Sommer et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)
Post-translational translocation into the endoplasmic reticulum
Nicholas Johnson et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)
A Network of Cytosolic Factors Targets SRP-Independent Proteins to the Endoplasmic Reticulum
Tslil Ast et al.
CELL (2013)
Fingerloop activates cargo delivery and unloading during cotranslational protein targeting
Aileen R. Ariosa et al.
MOLECULAR BIOLOGY OF THE CELL (2013)
The Signal Sequence Influences Post-Translational ER Translocation at Distinct Stages
Nicholas Johnson et al.
PLOS ONE (2013)
Cotranslational folding of membrane proteins probed by arrest-peptide-mediated force measurements
Florian Cymer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes
Eunyong Park et al.
ANNUAL REVIEW OF BIOPHYSICS, VOL 41 (2012)
BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER
Nico Schaeuble et al.
EMBO JOURNAL (2012)
TRC40 can deliver short secretory proteins to the Sec61 translocon (vol 125, pg 3612, 2012)
Nicholas Johnson et al.
JOURNAL OF CELL SCIENCE (2012)
Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation
Asvin K. K. Lakkaraju et al.
MOLECULAR BIOLOGY OF THE CELL (2012)
Activated GTPase movement on an RNA scaffold drives co-translational protein targeting
Kuang Shen et al.
NATURE (2012)
Membrane Protein Insertion at the Endoplasmic Reticulum
Sichen Shao et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)
A Calmodulin-Dependent Translocation Pathway for Small Secretory Proteins
Sichen Shao et al.
CELL (2011)
Structural basis of signal-sequence recognition by the signal recognition particle
Tobias Hainzl et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Recognition of a signal peptide by the signal recognition particle
Claudia Y. Janda et al.
NATURE (2010)
A flavivirus signal peptide balances the catalytic activity of two proteases and thereby facilitates virus morphogenesis
Mario Lobigs et al.
VIROLOGY (2010)
Cotranslational and Posttranslational N-Glycosylation of Polypeptides by Distinct Mammalian OST Isoforms
Catalina Ruiz-Canada et al.
CELL (2009)
A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel
Uta Berndt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites
Asvin K. K. Lakkaraju et al.
CELL (2008)
A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum
Catherine Rabu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Signal sequence-independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel
Thomas Bornemann et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
The surprising complexity of signal sequences
Ramanujan S. Hegde et al.
TRENDS IN BIOCHEMICAL SCIENCES (2006)
Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes
Tracey C. Fleischer et al.
GENES & DEVELOPMENT (2006)
ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane
M Blau et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Regulation of protein compartmentalization expands the diversity of protein function
KL Shaffer et al.
DEVELOPMENTAL CELL (2005)
Substrate twinning activates the signal recognition particle and its receptor
PF Egea et al.
NATURE (2004)
Regulation of hepatitis C virus polyprotein processing by signal peptidase involves structural determinants at the p7 sequence junctions
S Carrère-Kremer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
X-ray structure of a protein-conducting channel
B van den Berg et al.
NATURE (2004)
Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens
JJ Flanagan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Roles of cytosolic Hsp70 and Hsp40 molecular chaperones in post-translational translocation of presecretory proteins into the endoplasmic reticulum
J Ngosuwan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane
RD Fons et al.
JOURNAL OF CELL BIOLOGY (2003)
Cleavage of a tail-anchored protein by signal peptidase
I Nilsson et al.
FEBS LETTERS (2002)
Signal sequences control gating of the protein translocation channel in a substrate-specific manner
SJ Kim et al.
DEVELOPMENTAL CELL (2002)
The conformation of bound GMPPNP suggests a mechanism for gating the active site of the SRP GTPase
S Padmanabhan et al.
STRUCTURE (2001)
In vivo kinetics of protein targeting to the endoplasmic reticulum determined by site-specific phosphorylation
V Goder et al.
EMBO JOURNAL (2000)
Elongation arrest is a physiologically important function of signal recognition particle
N Mason et al.
EMBO JOURNAL (2000)
Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomes
J Tyedmers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Mammalian Sec61 is associated with Sec62 and Sec63
HA Meyer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)