Journal
ENDOCRINE
Volume 72, Issue 1, Pages 1-11Publisher
SPRINGER
DOI: 10.1007/s12020-021-02671-8
Keywords
Vitamin D; Hypocalcemia; Vertebral fractures; Diabetes mellitus; Obesity; COVID-19
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The review suggests that there may be an endocrine phenotype related to COVID-19, with a correlation between 25 hydroxyvitamin D levels and different clinical outcomes of the disease. Therefore, various endocrine manifestations of COVID-19 could potentially be explained in the context of inadequate vitamin D status.
Background Vitamin D and its deficiency have recently been suspected to be involved in increased susceptibility and negative outcomes of COVID-19. This assumption was based on the well known immunomodulatory actions of vitamin D and on the consistent finding of low levels of 25 hydroxyvitamin D (25OHD) in hospitalized patients with COVID-19. Moreover, several studies reported a correlation between 25OHD levels and different clinical outcomes of the disease. Aim Aim of the current review was to approach the topic of vitamin D and COVID-19 from a different perspective summarizing the data which led to the evidence of the existence of an endocrine phenotype of COVID-19. Conclusions This review analyzed in the light of the current knowledge the possibility that several endocrine manifestations of COVID-19 could be holistically interpreted in the context of an inadequate vitamin D status.
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