Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 41, Pages 48403-48413Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c14979
Keywords
antibiofilm surface; antifouling polymer; photothermal effect; tannic acid/Cu ion complex; poly(ethylene glycol)
Funding
- National Natural Science Foundation of China [21774086, 22175125, 21935008]
- Natural Science Foundation of Jiangsu Province [BK20180093]
- Suzhou Municipal Science and Technology Foundation [SYS2018026]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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A facile method has been developed to endow diverse substrates with long-term antibiofilm property by deposition of a hybrid film composed of tannic acid/Cu ion complex and poly(ethylene glycol). This system shows great potential for practical applications to solve the biofilm-associated problems of biomedical materials and devices by preventing biofilm formation effectively.
Biofilms formed from the pathogenic bacteria that attach to the surfaces of biomedical devices and implantable materials result in various persistent and chronic bacterial infections, posing serious threats to human health. Compared to the elimination of matured biofilms, prevention of the formation of biofilms is expected to be a more effective way for the treatment of biofilm-associated infections. Herein, we develop a facile method for endowing diverse substrates with long-term antibiofilm property by deposition of a hybrid film composed of tannic acid/Cu ion (TA/Cu) complex and poly(ethylene glycol) (PEG). In this system, the TA/Cu complex acts as a multifunctional building block with three different roles: (i) as a versatile glue with universal adherent property for substrate modification, (ii) as a photothermal biocidal agent for bacterial elimination under irradiation of near-infrared (NIR) laser, and (iii) as a potent linker for immobilization of PEG with inherent antifouling property to inhibit adhesion and accumulation of bacteria. The resulted hybrid film shows negligible cytotoxicity and good histocompatibility and could prevent biofilm formation for at least 15 days in vitro and suppress bacterial infection in vivo, showing great potential for practical applications to solve the biofilm-associated problems of biomedical materials and devices.
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