Journal
BIOENGINEERING-BASEL
Volume 8, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/bioengineering8050067
Keywords
hematopoietic stem cells; decision-making; stem cell niches; cytokines
Funding
- European Union [315902]
Ask authors/readers for more resources
Hematopoietic stem cells and their progeny interact with the environment and cytokines, affecting the generation of blood and immune cells. Recent studies show that adult bone marrow HSCs are a mixture of different cells, and cytokines can also guide cell lineage selection.
Like all cells, hematopoietic stem cells (HSCs) and their offspring, the hematopoietic progenitor cells (HPCs), are highly sociable. Their capacity to interact with bone marrow niche cells and respond to environmental cytokines orchestrates the generation of the different types of blood and immune cells. The starting point for engineering hematopoiesis ex vivo is the nature of HSCs, and a longstanding premise is that they are a homogeneous population of cells. However, recent findings have shown that adult bone marrow HSCs are really a mixture of cells, with many having lineage affiliations. A second key consideration is: Do HSCs choose a lineage in a random and cell-intrinsic manner, or are they instructed by cytokines? Since their discovery, the hematopoietic cytokines have been viewed as survival and proliferation factors for lineage committed HPCs. Some are now known to also instruct cell lineage choice. These fundamental changes to our understanding of hematopoiesis are important for placing niche support in the right context and for fabricating an ex vivo environment to support HSC development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available