Rectal cancer management during the COVID-19 pandemic (ReCaP): multicentre prospective observational study

Article Oncology

The impact of the COVID-19 pandemic on radiotherapy services in England, UK: a population-based study

Katie Spencer et al.

Summary: The study evaluated the impact of COVID-19 on radiotherapy activity in England, finding a significant decrease in radiotherapy courses and attendance during the pandemic. However, there was an increase in treatments for some cancers, particularly with the rapid increase in the use of hypofractionated regimens.

LANCET ONCOLOGY (2021)

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Article Oncology

Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial

Renu R. Bahadoer et al.

Summary: The RAPIDO trial aimed to reduce systemic relapses in locally advanced rectal cancer through short-course radiotherapy, chemotherapy, and delayed surgery. Results showed a decreased probability of disease-related treatment failure in the experimental group compared to standard care, with diarrhea being the most common adverse event and neurological toxicity being prominent in the standard care group during adjuvant chemotherapy.

LANCET ONCOLOGY (2021)

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Article Gastroenterology & Hepatology

Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study

Simon P. Bach et al.

Summary: An organ-preserving strategy with selective total mesorectal excision could be a feasible treatment option for early-stage rectal cancer, achieving high levels of organ preservation with relatively low morbidity and indications of improved quality of life. Further evaluation is needed to assess the long-term oncological outcomes of organ preservation in comparison to radical surgery.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Oncology