Journal
TRANSLATIONAL NEUROSCIENCE
Volume 12, Issue 1, Pages 533-544Publisher
DE GRUYTER POLAND SP Z O O
DOI: 10.1515/tnsci-2020-0195
Keywords
calcidiol; calcitriol; concussion; traumatic brain injury; vitamin D receptor
Categories
Funding
- National Institutes of Health [NS095166, NS103036, NS110008, NS116076]
- Department of Defense [AZ180127]
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Vitamin D supplementation has been shown to improve patient outcomes in various illnesses, while deficiencies may worsen symptoms. Research on the effects of vitamin D in traumatic brain injury is still in its early stages, with much to be learned about its potential benefits.
Vitamin D supplementation has been shown to improve outcomes for patients suffering from a variety of illnesses such as stroke and cancer. Vitamin D deficiencies have been associated with longer hospital stays, greater severity of symptoms, and death in some complex cases. Due to vitamin D's burgeoning role in improving patient outcomes, a new sector of research is focusing on the lesser-known implications of vitamin D on health. Traumatic brain injury (TBI) affects approximately 69 million people worldwide per year. Here, we summarize the current scientific understanding of vitamin D dynamics with TBI to elucidate a potential way to lessen the cascade of secondary damage after an initial insult, with the goal of improving overall patient outcomes. Because vitamin D supplementation has been correlated with better outcomes in other pathologies involving immune and inflammatory molecules, it is important to study the potential effect of vitamin D deficiency (VDD) and supplementation on TBI outcomes. Research on vitamin D supplementation in TBI remains in the preliminary stages. There is still much to learn about vitamin D deficiency, dosage, variants of supplementary forms, mechanisms, and its role in TBI.
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