Journal
NICOTINE & TOBACCO RESEARCH
Volume 23, Issue 7, Pages 1153-1159Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ntr/ntab013
Keywords
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Funding
- Cancer Research UK [C50878/A21130, C1417/A22962]
- NIH National Institute on Drug Abuse (NIDA) [R01DA037446]
- NIH National Cancer Institute (NCI)/US Food and Drug Administration (FDA) [DA U54CA228110]
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The study found that vapers compensate for low nicotine delivery by taking longer puffs under fixed power conditions, and this compensatory behavior remains stable when power settings are adjustable.
Introduction: In a secondary analysis of our published data demonstrating compensatory vaping behavior (increased puff number, puff duration, and device power) with e-cigarettes refilled with low versus high nicotine concentration e-liquid, here we examine 5-day time course over which compensatory behavior occurs under fixed and adjustable power settings. Aims and Methods: Nineteen experienced vapers (37.90 +/- 10.66 years, eight females) vaped ad libitum for 5 consecutive days under four counterbalanced conditions (ie, 20 days in total): (1) low nicotine (6 mg/mL)/fixed power (4.0V/10 W); (2) low nicotine/adjustable power; (3) high nicotine (18 mg/mL)/fixed power; (4) high nicotine/adjustable power (at 1.6 Ohm). Puff number, puff duration, and power settings were recorded by the device. For each day, total daily puffing time was calculated by multiplying daily puff number by mean daily puff duration. Results: A significant day x setting interaction revealed that whilst puffing compensation (daily puffing time) continued to increase over 5 days under fixed power, it remained stable when power settings were adjustable. Separate analysis for puff number and puff duration suggested that the puffing compensatory behavior was largely maintained via longer puff duration. Conclusions: Under fixed power conditions (4.0 V/10 W), vapers appear to compensate for poor nicotine delivery by taking longer puffs and this compensatory puffing appears to be maintained over time.
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