Journal
AGING-US
Volume 13, Issue 23, Pages 25180-25194Publisher
IMPACT JOURNALS LLC
Keywords
licochalcone A; adipose-derived stem cells; cell proliferation; glycolysis; aging
Categories
Funding
- National Key Research and Development Program [2020YFC2002800]
- National Natural Science Foundation of China [31671539]
- Major Program of Development Fund for Shanghai Zhangjiang National Innovation Demonstration Zone [ZJ2018-ZD-004]
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The study indicates that licochalcone A (LA) has anti-aging effects in adipose-derived stem cells by activating the glycolysis pathway.
Licochalcone A (LA) is a chalcone flavonoid of Glycyrrhiza inflata, which has anti-cancer, antioxidant, antiinflammatory, and neuroprotective effects. However, no anti-aging benefits of LA have been demonstrated in vitro or in vivo. In this study, we explored whether LA has an anti-aging effect in adipose-derived stem cells (ADSCs). We performed beta-galactosidase staining and measured reactive oxygen species, relative telomere lengths, and P16(ink4a) mRNA expression. Osteogenesis was assessed by Alizarin Red staining and adipogenesis by was assessed Oil Red O staining. Protein levels of related markers runt-related transcription factor 2 and lipoprotein lipase were also examined. RNA sequencing and measurement of glycolysis activities showed that LA significantly activated glycolysis in ADSCs. Together, our data strongly suggest that the LA have an anti-aging effect through activate the glycolysis pathway.
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