Journal
COSMETICS
Volume 8, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/cosmetics8040107
Keywords
Mesua ferrea; anti-acne; anti-bacteria; anti-inflammation; anti-oxidant; anti-tyrosinase
Categories
Funding
- Ramkhamhaeng University
- Center of Excellence for Innovation in Chemistry (PERCH-CIC)
- Ministry of Higher Education,Science, Research and Innovation
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Mesua ferrea (M. ferrea) flower extract shows bactericidal effects against Staphylococcus epidermidis and Staphylococcus aureus, bacteriostatic effect against Cutibacterium acnes, anti-inflammatory activity, and moderate to weak antioxidant properties. It may serve as an alternative natural anti-acne formulation.
Acne vulgaris is a common chronic inflammatory skin disease. In the present study, we reported the anti-acne vulgaris effect of the Mesua ferrea (M. ferrea) flower extract. The extract was evaluated for three anti-acne-causing bacteria properties including Cutibacterium acnes (C. acnes), Staphylococcus epidermidis (S. epidermidis) and Staphylococcus aureus (S. aureus). The results indicated that the M. ferrea flower extract could be considered as the bactericidal agent against S. epidermidis and S. aureus with MIC values of 0.78 and 6.25 mg mL(-1) and MBC values of 1.56 and 12.50 mg mL(-1) and the bacteriostatic agent against C. acnes with MIC and MBC values of 3.12 and 25.00 mg mL(-1), respectively. The extract at a concentration of 25 mu g mL(-1) also presented potent anti-inflammatory activity with a significant decrease of nitric oxide (NO) and tumor necrosis factor (TNF)-alpha productions in RAW 264.7 macrophage cells stimulated by LPS. In addition, the extract showed moderate to weak anti-oxidative capacities against DPPH, ABTS, FRAP and NO assays and also showed weak anti-tyrosinase activity. M. ferrea flower extract may serve as the alternative natural anti-acne formulations.
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