4.4 Article

Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives

Related references

Note: Only part of the references are listed.
Review Genetics & Heredity

CCN Family Proteins in Cancer: Insight Into Their Structures and Coordination Role in Tumor Microenvironment

Qingan Jia et al.

Summary: The communication between tumor cells and TME activates signaling pathways that contribute to cancer progression. Targeting multiple components rather than single molecules could be more effective in cancer therapy, with CCN family proteins showing promise. The diverse functions of CCN proteins in different cancers are influenced by the TME and its truncated isoforms, suggesting a potential anti-cancer strategy by targeting CCN proteins to rebalance the TME.

FRONTIERS IN GENETICS (2021)

Article Pharmacology & Pharmacy

CCN5 activation by free or encapsulated EGCG is required to render triple-negative breast cancer cell viability and tumor progression

Amlan Das et al.

Summary: This study demonstrates that EGCG activates CCN5 to inhibit in vitro cell viability, reverse TNBC cells' stemness, and suppress tumor growth. Additionally, EGCG-loaded nanoparticles are found to be more effective in suppressing tumors compared to free-EGCG.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2021)

Article Pharmacology & Pharmacy

Assessment of Genotoxic potential of Annonacin and Annona muricata L. extracts on human breast cancer (MCF-7) cells

Aditi Venkatesh Naik et al.

Summary: The use of plants, like Annona muricata, for cancer treatment is common globally. This study aimed to investigate the genotoxic effects of leaf and pulp extracts compared to the compound Annonacin on breast cancer cells. Results showed that leaf extracts exhibited higher genotoxic potential than pulp extracts but were less effective than Annonacin. Further research on safety evaluation and genotoxicity endpoints is needed.

ADVANCES IN TRADITIONAL MEDICINE (2021)

Review Oncology

Regulation of breast cancer metastasis signaling by miRNAs

Belinda J. Petri et al.

CANCER AND METASTASIS REVIEWS (2020)

Article Biochemistry & Molecular Biology

Effects of synthetic glucocorticoids on breast cancer progression

Jia Meng Pang et al.

STEROIDS (2020)

Article Pharmacology & Pharmacy

RU486 Metabolite Inhibits CCN1/Cyr61 Secretion by MDA-MB-231-Endothelial Adhesion

Suhong Yu et al.

FRONTIERS IN PHARMACOLOGY (2019)

Editorial Material Cell Biology

CCN proteins are part of a multilayer complex system: a working model

Bernard Perbal

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2019)

Article Biochemistry & Molecular Biology

Predicting Potential Drugs for Breast Cancer based on miRNA and Tissue Specificity

Liang Yu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Review Cell Biology

The matricellular protein CCN1 in tissue injury repair

Ki-Hyun Kim et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2018)

Review Cell Biology

Matricellular CCN6 (WISP3) protein: a tumor suppressor for mammary metaplastic carcinomas

Mai N. Tran et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2018)

Review Biochemistry & Molecular Biology

Role of the CCN protein family in cancer

Hyungjoo Kim et al.

BMB REPORTS (2018)

Review Biochemistry & Molecular Biology

Emerging Biological Principles of Metastasis

Arthur W. Lambert et al.

Review Cell Biology

CCN family of proteins: critical modulators of the tumor cell microenvironment

Herman Yeger et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2016)

Review Cell Biology

Dual roles of CCN proteins in breast cancer progression

Celina G. Kleer

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2016)

Review Cell Biology

Cell surface receptors for CCN proteins

Lester F. Lau

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2016)

Review Medicine, Research & Experimental

Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)

Jun Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2015)

Article Multidisciplinary Sciences

WNT-1 inducible signaling pathway protein-1 enhances growth and tumorigenesis in human breast cancer

Kun-Chun Chiang et al.

SCIENTIFIC REPORTS (2015)

Review Oncology

Dosing of zoledronic acid with its anti-tumor effects in breast cancer

Xinmin Zhao et al.

JOURNAL OF BONE ONCOLOGY (2015)

Review Oncology

New strategy to control cell migration and metastasis regulated by CCN2/CTGF

Diego Pinheiro Aguiar et al.

CANCER CELL INTERNATIONAL (2014)

Article Oncology

Functional domains of CCN1 (Cyr61) regulate breast cancer progression

James O'Kelly et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

Article Cell Biology

CCN1 promotes vascular endothelial growth factor secretion through αvβ3 integrin receptors in breast cancer

Ingrid Espinoza et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2014)

Review Oncology

miRNA Dysregulation in Breast Cancer

Laoighse Mulrane et al.

CANCER RESEARCH (2013)

Article Multidisciplinary Sciences

Foxo3a Expression Is a Prognostic Marker in Breast Cancer

Ying Jiang et al.

PLOS ONE (2013)

Article Cell Biology

Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family

Tarek Abd El Kader et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2013)

Article Cell Biology

On how CCN6 suppresses breast cancer growth and invasion

Wei Huang et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2012)

Review Cell Biology

CCN5/WISP-2: A micromanager of breast cancer progression

Sushanta K. Banerjee et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2012)

Review Biochemistry & Molecular Biology

The CCN family: A new class of inflammation modulators?

L. Kular et al.

BIOCHIMIE (2011)

Review Biochemistry & Molecular Biology

Roles for CCN2 in normal physiological processes

Faith Hall-Glenn et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

Article Biochemistry & Molecular Biology

WNT1 inducible signaling pathway protein 1 (WISP1): A novel mediator linking development and disease

Barbara Berschneider et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

CCN5, a Novel Transcriptional Repressor of the Transforming Growth Factor β Signaling Pathway

Michele Sabbah et al.

MOLECULAR AND CELLULAR BIOLOGY (2011)

Article Oncology

CCN1, a Candidate Target for Zoledronic Acid Treatment in Breast Cancer

Ingrid Espinoza et al.

MOLECULAR CANCER THERAPEUTICS (2011)

Review Biotechnology & Applied Microbiology

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

Joon-Il Jun et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Review Cell Biology

CCN5: biology and pathophysiology

Joshua W. Russo et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2010)

Article Biochemistry & Molecular Biology

Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF

Deo Prakash Pandey et al.

EMBO JOURNAL (2009)

Review Biochemistry & Molecular Biology

Functions and mechanisms of action of CCN matricellular proteins

Chih-Chiun Chen et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

Article Cell Biology

CCN5 expression in mammals

Jennifer A. Jones et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2007)