Journal
ENVIRONMENTAL POLLUTION
Volume 220, Issue -, Pages 1199-1207Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2016.11.015
Keywords
High throughput screening; Pharmaceutical compounds; Photocatalysis; Titanium dioxide; Water treatment; Reactant selectivity
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Funding
- NanoNextNL, a micro and nano technology consortium of the Government of the Netherlands
- COMPETE in the context of the project Stem cell based platforms for Regenerative and Therapeutic Medicine [Centro-07-ST24-FEDER-002008]
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The susceptibility for photon-induced degradation of over 800 pharmaceutical compounds present in the LOPAC(1280) library, was analyzed by UV/Vis spectroscopy in the absence or presence of TiO2 P25 in water. In general, few compounds were effectively degraded in the absence of the TiO2 photocatalyst (3% of all compounds tested), while in the presence of TiO2, the majority of compounds was converted, often to a large degree. Differences in degree of degradation are evaluated on the basis of molecular weight, as well as the chemical nature of the drug compounds (functional groups and pharmacological classes). In general, if the molecular weight increases, the degradation efficacy decreases. Relatively high degrees of conversion can be achieved for (relatively small) molecules with functional groups such as aldehydes, alcohols, ketones and nitriles. A low degree of conversion was observed for compounds composed of conjugated aromatic systems. Trends in degradation efficacy on the basis of pharmacological class, e.g. comparing hormones and opioids, are not obvious. (C) 2016 Elsevier Ltd. All rights reserved.
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