Journal
REVIEWS IN CARDIOVASCULAR MEDICINE
Volume 22, Issue 4, Pages 1693-1700Publisher
IMR PRESS
DOI: 10.31083/j.rcm2204177
Keywords
Optical coherence tomography; Neoatherosclerosis; Non-culprit lesion
Categories
Funding
- National Natural Science Foundation of China [81801803]
- China Postdoctoral Science Foundation [2018M640310]
- Heilongjiang Postdo Methodology ctoral Science Foundation [LBH-Z19032]
- Fund of Key Laboratory of Myocardial Ischemia, Ministry of Education
Ask authors/readers for more resources
The study found that patients with in-stent neoatherosclerosis (ISNA) had smaller minimum lumen area, greater decrease, and more plaques with lipid core length increase in non-culprit lesions, suggesting a possible link between ISNA formation and delayed plaque stabilization in non-culprit lesions.
The relationship between the in-stent neoatherosclerosis (ISNA) formation and the plaque's characteristic changes in the non-culprit lesion is unclear. We aim to investigate the plaque characteristics changes at non-culprit lesions between patients with ISNA and without ISNA formation at 1-year follow-up. We retrospectively enrolled patients who had DES implantation in de novo lesion and underwent immediately after stenting and 1-year follow-up optical coherence tomography (OCT) examination. OCT-defined ISNA was defined as the presence of lipid-laden neointima or calcification within the culprit stent with a longitudinal extension of >= 1 mm. Non-culprit lesions were divided into two groups: ISNA group (with ISNA) and non-ISNA group (without ISNA). Plaque characteristics of non-culprit lesions were evaluated at baseline and 1-year follow-up. In total, 89 patients with 89 non-culprit lesions (ISNA: n = 37; non-ISNA: n = 52) were included in the analyses. The lesions in the ISNA group show a smaller minimum lumen area compared to the non-ISNA group at 1-year follow-up (2.57 +/- 1.08 mm(2) versus 3.20 +/- 1.62 mm(2), p = 0.044). The lesions of the ISNA group show a significant decrease in minimum lumen area changes percent (-7.25% versus 6.46%, p = 0.039). And there are more lesions with minimum lumen area (64.9% versus 38.5%, p = 0.014) and minimum lumen diameter (64.9% versus 40.4%, p = 0.023) decrease in the ISNA group. Furthermore, the lesions in ISNA group have more plaques with lipid core length increase (25.0% versus 10.0%, p = 0.040), more plaques with FCT decrease (50.0% versus 74.0%, p = 0.027) and less TCFA change to non-TCFA (33.3% versus 87.5%, p = 0.010). The plaque characteristic changes in non-culprit lesions are closely related to ISNA formation. The ISNA formation may accompany by a tardier plaque stabilization process in non-culprit lesions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available