Journal
GELS
Volume 7, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/gels7040263
Keywords
stem cell; hydrogel; osteoarthritis; cartilage repair
Categories
Funding
- Nanning Qingxiu District Science and Technology Plan Project [2020018]
- National Natural Science Foundation of China [81760390]
- Guangxi Natural Science Foundation [2018GXNSFAA294075]
- Guangxi Science and Technology Base and Talent Special Project [GuikeAD19254003]
- Shenzhen Institutes of Advanced Technology Innovation Program for Excellent Young Researchers [Y9G075]
- Shenzhen Institute of Synthetic Biology Scientific Research Program [DWKF20190010, JCHZ20200005]
- Medical Excellence Award - Creative Research Development Grant from the First Affiliated Hospital of Guangxi Medical University
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Stem cells hold promise for cartilage repair in osteoarthritis, but challenges in large-scale production, viability maintenance, and therapeutic activity hinder clinical application. Advanced hydrogel technologies, particularly microgels and dynamic hydrogel systems, show potential in improving stem cell survival and regulation of stem cell fate.
Stem cells hold tremendous promise for the treatment of cartilage repair in osteoarthritis. In addition to their multipotency, stem cells possess immunomodulatory effects that can alleviate inflammation and enhance cartilage repair. However, the widely clinical application of stem cell therapy to cartilage repair and osteoarthritis has proven difficult due to challenges in large-scale production, viability maintenance in pathological tissue site and limited therapeutic biological activity. This review aims to provide a perspective from hydrogel-focused approach to address few key challenges in stem cell-based therapy for cartilage repair and highlight recent progress in advanced hydrogels, particularly microgels and dynamic hydrogels systems for improving stem cell survival, retention and regulation of stem cell fate. Finally, progress in hydrogel-assisted gene delivery and genome editing approaches for the development of next generation of stem cell therapy for cartilage repair in osteoarthritis are highlighted.
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