Repair of Peripheral Nerve Injury Using Hydrogels Based on Self-Assembled Peptides

Peripheral nerve injury often occurs in young adults and is characterized by complex regeneration mechanisms, poor prognosis, and slow recovery, which not only creates psychological obstacles for the patients but also causes a significant burden on society, making it a fundamental problem in clinical medicine. Various steps are needed to promote regeneration of the peripheral nerve. As a bioremediation material, self-assembled peptide (SAP) hydrogels have attracted international attention. They can not only be designed with different characteristics but also be applied in the repair of peripheral nerve injury by promoting cell proliferation or drug-loaded sustained release. SAP hydrogels are widely used in tissue engineering and have become the focus of research. They have extensive application prospects and are of great potential biological value. In this paper, the application of SAP hydrogel in peripheral nerve injury repair is reviewed, and the latest progress in peptide composites and fabrication techniques are discussed.

Automated summary

Peripheral nerve injury is common in young adults and has complex regeneration mechanisms, slow recovery, and poor prognosis, causing a significant burden on patients and society. Self-assembled peptide (SAP) hydrogels, as a bioremediation material, have attracted international attention for their potential in promoting cell proliferation and drug-loaded sustained release for repairing peripheral nerve injuries. They have extensive application prospects and great biological value.