Journal
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
Volume 13, Issue 11, Pages 12694-12703Publisher
E-CENTURY PUBLISHING CORP
Keywords
Renal cell carcinoma; miR-103a-3p; TMEM33; proliferation; metastasis
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miR-103a-3p promotes renal cell carcinoma cell progression by regulating TMEM33. This finding may offer new insights into the identification of prognostic markers and therapeutic targets for RCC.
Objective: We investigated the mechanism of miR-103a-3p-mediated renal cell carcinoma (RCC) progression. Methods: The miR-103a-3p expressions were measured in clinical samples and in two RCC cell lines. MiR-103a-3p was inhibited or over-expressed in the 786-0 and U031 cell lines, respectively. Results: We found that miR-103a-3p is closely related to the development of RCC cells. A bioinformatics analysis and a dual-luciferase reporter gene assay revealed that there is a direct interaction between TMEM33 and miR-103a-3p. Moreover, a rescue assay further confirmed that TMEM33 overexpression can attenuate miR-103a-3p-induced RCC cell development. Conclusion: miR-103a-3p exerts a carcinogenic function in RCC by regulating TMEM33, a finding that may provide new insights into the development of prognostic markers and therapeutic targets for RCC.
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