Establishment of an iodine model for prevention of iodine-excess-induced thyroid dysfunction in pregnant women

This study aims to explore the relationship between the iodine status and thyroid dysfunction (TD) in pregnant women and establish a model to guide them to prevent excessive iodine intake. A total of 515 pregnant women were enrolled in the study. Urinary iodine concentration (UIC), thyroid hormones, and thyroid autoantibodies were measured, and then a logistic regression model was established. The median UIC of pregnant women was 174 +/- 120 mu g/L. Multivariate logistic regression analysis indicated that multivitamin supplements containing iodine and frequent seafood consumption were risk factors for excessive iodine (UIC >= 500 mu g/L). Besides, excessive iodine was a risk factor for TD. Iodine excess was associated with a high prevalence of TD in pregnant women, especially TPOAb-positive women (P < 0.05). A logistic regression model based on potential risk factors was established to predict the risk of excessive iodine intake among pregnant women and provide guidance to minimize the risk of excessive iodine intake, thus reducing the risk of TD.

Automated summary

This study aimed to investigate the link between iodine status and thyroid dysfunction in pregnant women and developed a logistic regression model to predict excessive iodine intake. The findings revealed that multivitamin supplements with iodine and frequent seafood consumption were risk factors for excessive iodine intake, which was associated with a high prevalence of thyroid dysfunction especially in TPOAb-positive pregnant women.