Journal
ENVIRONMENTAL HEALTH PERSPECTIVES
Volume 125, Issue 9, Pages -Publisher
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
DOI: 10.1289/EHP1015
Keywords
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Funding
- French Agency for Food, Environmental and Occupational Health and Safety (ANSES)
- European Research Council [311765E-D0HaD]
- Foundation for Medical Research (FRM)
- National Agency for Research (ANR)
- National Institute for Research in Public health (IRESP)
- French Ministry of Health (DGS)
- French Ministry of Research
- INSERM Bone and Joint Diseases National Research (PRO-A)
- Human Nutrition National Research Programs
- Paris Sud University
- Nestle
- French National Institute for Population Health Surveillance (InVS)
- French National Institute for Health Education (INPES)
- European Union FP7 programme HELIX
- European Union FP7 programme ESCAPE
- European Union FP7 programme ENRIECO
- European Union FP7 programme Medall projects
- Diabetes National Research Program
- French Association of Diabetic Patients (AFD)
- Mutuelle Generale de l'Education Nationale (MGEN)
- French speaking association for the study of diabetes and metabolism (ALFEDIAM)
- University Grenoble-Alpes
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BACKGROUND: Phenols and phthalates may have immunomodulatory and proinflammatory effects and thereby adversely affect respiratory health. OBJECTIVE: We estimated the associations between gestational exposure to select phthalates and phenols and respiratory health in boys. METHODS: Among 587 pregnant women from the EDEN (Etude des Determinants pre du developpement et de la sante de l'Enfant) cohort who delivered a boy, 9 phenols and 11 phthalates metabolites were quantified in spot pregnancy urine samples. Respiratory outcomes were followed up by questionnaires until age 5, when forced expiratory volume in 1 s (FEV1) was measured by spirometry. Adjusted associations of urinary metabolites log-transformed concentrations with respiratory outcomes and FEV1 in percent predicted (FEV1%) were estimated by survival and linear regression models, respectively. RESULTS: No phenol or phthalate metabolite exhibited clear deleterious associations simultaneously with several respiratory outcomes. Ethyl-paraben was associated with increased asthma rate [hazard rate (HR) = 1.10; 95% confidence interval (CI): 1.00, 1.21] and tended to be negatively associated with FEV1% (beta = -0.59; 95% CI: -1.24, 0.05); bisphenol A tended to be associated with increased rates of asthma diagnosis (HR=1.23; 95% CI: 0.97, 1.55) and bronchiolitis/bronchitis (HR = 1.13; 95% CI: 0.99, 1.30). Isolated trends for deleterious associations were also observed between 2,5-dichlorophenol and wheezing, and between monocarboxynonyl phthalate, a metabolite of di-isodecyl phthalate (DIDP), and wheezing. CONCLUSION: Ethyl-paraben, bisphenol A, 2,5-dichlorophenol, and DIDP tended to be associated with altered respiratory health, with ethyl-paraben and bisphenol A exhibiting some consistency across respiratory outcomes. The trends between bisphenol A pregnancy level and increased asthma and bronchiolitis/bronchitis rates in childhood were consistent with a previous cohort study. https://doi.org/10.1289/EHP1015.
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