Journal
THERANOSTICS
Volume 11, Issue 7, Pages 3348-3358Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.45889
Keywords
peptidyl-prolyl cis-trans isomerases; Pin1; pathogenesis of diseases; viral infection; neurodegenerative diseases
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Funding
- National Natural Science Foundation of China [81772692]
- Scientific Research Program for Young Talents of China National Nuclear Corporation [2020CNNC74]
- Science & Technology Department of Sichuan Province [2018JY0368, 2019YJ0371]
- Health Commission of Sichuan Province [20PJ226]
- Chengdu Medical College [CYTD18-02]
- Suzhou University [KJS1962]
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Pin1, a member of the PPIases superfamily, catalyzes the cis-trans conversion of proline in target substrates to modulate cellular functions, and its dysregulation is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis.
Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis. Dysregulation of Pin1 has wide-ranging influences on the fate of cells; therefore, it is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis.
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