Journal
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
Volume 19, Issue -, Pages 5978-5986Publisher
ELSEVIER
DOI: 10.1016/j.csbj.2021.10.037
Keywords
Human endogenous retroviruses (HERVs); Embryonic development and pluripotency; Cancer; Aging; Neurodegenerative diseases
Funding
- National Natural Science Foundation of China [31730020, 32000512, 31801155]
- Hangzhou Science and Technology Bureau [20182014B01]
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HERVs make up about 8% of the human genome, originating from exogenous retroviral infections millions of years ago and inherited by offspring. While most HERVs are nonprotein-coding, they play important roles in human health and disease by encoding proteins, acting as promoters/enhancers, or lncRNAs.
Human endogenous retroviruses (HERVs) represent similar to 8% of human genome, deriving from exogenous retroviral infections of germ line cells occurred millions of years ago and being inherited by the offspring in a Mendelian fashion. Most of HERVs are nonprotein-coding because of the accumulation of mutations, insertions, deletions, and/or truncations. It has been long thought that HERVs were junk DNA. However, it is now known that HERVs are involved in various biological processes through encoding proteins, acting as promoters/enhancers, or lncRNAs to affect human health and disease. In this review, we summarized recent findings about HERVs, with implications in embryonic development, pluripotency, cancer, aging, and neurodegenerative diseases. (C) 2021 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
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