Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 17, Issue 15, Pages 4409-4425Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.64533
Keywords
Bone formation; Bone marrow stromal cells; Piwi-interacting RNAs; Wnt signaling
Categories
Funding
- Shenzhen Municipal Science and Technology Innovation Committee Project [JCYJ20180305164659637, SGLH20180625141602256, JSGG20180504170427135, JCYJ20180305164544288, JCYJ20190806160407178]
- Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration [ZDSYS20200811143752005]
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Bone remodeling is a dynamic process involving bone formation and resorption. PiRNA-63049, through the Wnt2b/13-β-catenin signaling pathway, has been shown to inhibit bone formation, making it a potential target for increasing bone formation in disorders such as postmenopausal osteoporosis.
Bone remodeling is a dynamic process between bone formation mediated by osteoblasts and bone resorption mediated by osteoclasts. Disrupted bone remodeling is a key factor in postmenopausal osteoporosis, a metabolic disorder characterized by deteriorated bone microarchitecture and increased risk of fracture. Recent studies have shown that piwi-binding RNA (piRNA) is involved in the pathogenesis of certain diseases at the post-transcriptional level. Here, we analyzed piRNA-63049 (piR-63049), which may play an essential role in bone remodeling. The expression of piR-63049 significantly increased in both bone tissues and plasma of osteoporotic rats and postmenopausal osteoporotic patients. Overexpressing piR-63049 could inhibit the osteoblastogenesis of bone marrow stromal cells (BMSCs) while knocking down piR-63049 could promote the osteoblastogenesis of BMSCs through the Wnt2b/13-catenin signaling pathway. Moreover, knocking-down piR-63049 (piR-63049-antagonist) in vivo could attenuate the bone loss in ovariectomized rats by promoting bone formation. Taken together, the current study shows that piR-63049 inhibits bone formation through the Wnt2b/13-catenin signaling pathway. This novel piRNA may be a potential target to increase bone formation in bone loss disorders such as postmenopausal osteoporosis.
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