Journal
HETEROCYCLES
Volume 103, Issue 2, Pages 661-669Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-20-S(K)43
Keywords
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Categories
Funding
- Hoansha Foundation
- Pharmaceutical Society of Japan [N-195302]
- [JP18K06590]
- [JP19K23815]
- [JP19K05467]
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A copper-mediated domino reaction has been developed for the synthesis of 4-bromo-1-bromoalkyl-5-aryl/alkyl/alkenyl-pyrazoles from N,N-disubstituted hydrazones. This method allows for the simultaneous construction of pyrazoles and two C-Br bonds, offering synthetic utility.
A copper-mediated domino reaction involving cyclization, bromination, and nucleophilic substitution of N,N-disubstituted hydrazones, which are labile under oxidative conditions, to synthesize 4-bromo- 1-bromoalkyl-5-aryl/alkyl/alkenyl-pyrazoles, is achieved. This method features the simultaneous construction of pyrazoles and two C-Br bonds, which are synthetically useful.
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