Related references
Note: Only part of the references are listed.Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay
Steven M. Bryce et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2017)
Threshold and non-threshold chemical carcinogens: A survey of the present regulatory landscape
Ruth J. Bevan et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2017)
The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding
Giel Hendriks et al.
TOXICOLOGICAL SCIENCES (2016)
Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach
Steven M. Bryce et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2016)
Dopamine induces mitochondrial depolarization without activating PINK1-mediated mitophagy
Heather Bondi et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays
James Whitwell et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2015)
Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay
Jennifer R. Cheung et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2015)
Assessment of mechanisms driving non-linear dose-response relationships in genotoxicity testing
M. Guerard et al.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2015)
An update on PARP inhibitors-moving to the adjuvant setting
Amir Sonnenblick et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2015)
A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells
Andrew Williams et al.
DATA IN BRIEF (2015)
The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events
Ted W. Simon et al.
CRITICAL REVIEWS IN TOXICOLOGY (2014)
Interpreting In Vitro Micronucleus Positive Results: Simple Biomarker Matrix Discriminates Clastogens, Aneugens, and Misleading Positive Agents
Steven M. Bryce et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2014)
AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissues
Gloria Juan et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2014)
Cyclin-Dependent Kinase Inhibitors as Marketed Anticancer Drugs: Where Are We Now? A Short Survey
Gaele Mariaule et al.
MOLECULES (2014)
Benzo[a]pyrene-induced cell cycle arrest in HepG2 cells is associated with delayed induction of mitotic instability
Dimitris Stellas et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2014)
The predominant role of apoptosis in γH2AX formation induced by aneugens is useful for distinguishing aneugens from clastogens
Asako Harada et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2014)
A comparative study of the aneugenic and polyploidy-inducing effects of fisetin and two model Aurora kinase inhibitors
P. Gollapudi et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2014)
PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1
Marie-France aEuro Langelier et al.
NUCLEIC ACIDS RESEARCH (2014)
The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response
Teodora Nikolova et al.
TOXICOLOGICAL SCIENCES (2014)
Way forward in case of a false positive in vitro genotoxicity result for a cosmetic substance?
Tatyana Y. Doktorova et al.
TOXICOLOGY IN VITRO (2014)
Usefulness of Monitoring γ-H2AX and Cell Cycle Arrest in HepG2 Cells for Estimating Genotoxicity Using a High-Content Analysis System
Masamitsu Ando et al.
JOURNAL OF BIOMOLECULAR SCREENING (2014)
Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells
Sabry M. Attia
JOURNAL OF APPLIED TOXICOLOGY (2013)
A combination of in vitro comet assay and micronucleus test using human lymphoblastoid TK6 cells
Aoi Kimura et al.
MUTAGENESIS (2013)
Regulation of brefeldin A-induced ER stress and apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase
Jung Lee Moon et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Reduction of misleading (false) positive results in mammalian cell genotoxicity assays. I. Choice of cell type
Paul Fowler et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2012)
Nongenotoxic Apoptosis Inducers Do Not Produce Misleading Positive Results in the TK6 Cell-Based GADD45a-GFP Genotoxicity Assay
Caroline H. Topham et al.
TOXICOLOGICAL SCIENCES (2012)
Efficient Monitoring of In Vivo Pig-a Gene Mutation and Chromosomal Damage: Summary of 7 Published Studies and Results From 11 New Reference Compounds
Stephen D. Dertinger et al.
TOXICOLOGICAL SCIENCES (2012)
How accurate is in vitro prediction of carcinogenicity?
Richard Maurice Walmsley et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Use of threshold and mode of action in risk assessment
Kenny S. Crump
CRITICAL REVIEWS IN TOXICOLOGY (2011)
Miniaturized Flow Cytometry-Based CHO-K1 Micronucleus Assay Discriminates Aneugenic and Clastogenic Modes of Action
Steven M. Bryce et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2011)
Comparison of In Vitro Micronucleus and Gene Mutation Assay Results for p53-Competent Versus p53-Deficient Human Lymphoblastoid Cells
Masamitsu Honma et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2011)
Potential thresholds for genotoxic effects by micronucleus scoring
Azeddine Elhajouji et al.
MUTAGENESIS (2011)
The incidence of positive results in the mouse lymphoma TK assay (MLA) in pharmaceutical screening and their prediction by MultiCase MC4PC
Michael D. Fellows et al.
MUTAGENESIS (2011)
Genotoxicity screening via the γH2AX by flow assay
D. J. Smart et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2011)
Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from working group on toxicity measures and top concentration for in vitro cytogenetics assays (chromosome aberrations and micronucleus)
Sheila Galloway et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2011)
Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines
Marc Payton et al.
CANCER RESEARCH (2010)
Further evaluation of a flow cytometric in vitro micronucleus assay in CHO-K-1 cells: a reliable platform that detects micronuclei and discriminates apoptotic bodies
Jing Shi et al.
MUTAGENESIS (2010)
Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test without cytokinesis block
Leigh Hynes
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2010)
GADD45a-GFP GreenScreen HC assay results for the ECVAM recommended lists of genotoxic and non-genotoxic chemicals for assessment of new genotoxicity tests
Louise Birrell et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2010)
TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use
Magali Olivier et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Nonlinear Cancer Response at Ultralow Dose: A 40800-Animal ED001 Tumor and Biomarker Study
George S. Bailey et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2009)
Molecular Cytogenetic Evaluation of the Mechanism of Micronuclei Formation Induced by Camptothecin, Topotecan, and Irinotecan
Sabry M. Attia et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2009)
H2AX phosphorylation as a genotoxicity endpoint
Gary Peter Watters et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2009)
Literature review on the genotoxicity, reproductive toxicity, and carcinogenicity of ethyl methanesulfonate
Elmar Gocke et al.
TOXICOLOGY LETTERS (2009)
Cytotoxic and genotoxic effects of matrices for cartilage tissue engineering
Amelie S. Lotz et al.
TOXICOLOGY LETTERS (2009)
Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity
Heidrun Ellinger-Ziegelbauer et al.
TOXICOLOGY LETTERS (2009)
Caffeine induces cell death via activation of apoptotic signal and inactivation of survival signal in human osteoblasts
Pin-Zhen Lu et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2008)
Antitumor effect of dsRNA-induced p21WAF1/CIP1 gene activation in human bladder cancer cells
Zhong Chen et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Assessment of DNA double-strand breaks and γH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone
Daniel J. Smart et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2008)
Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test II:: Practical aspects with toxic agents
Michael D. Fellows et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2008)
Executioner caspase-3 and caspase-7 are functionally distinct proteases
John G. Walsh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests:: Report of an ECVAM Workshop
David Kirkland et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2007)
Meta-analysis of the p53 mutation database for mutant p53 biological activity reveals a methodologic bias in mutation detection
T Soussi et al.
CLINICAL CANCER RESEARCH (2006)
Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines
QH Shi et al.
NATURE (2005)
Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage
L Monaco et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens -: I.: Sensitivity, specificity and relative predictivity
D Kirkland et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2005)
Effects of acute and chronic cyclophosphamide treatment on meiotic progression and the induction of DNA double-strand breaks in rat spermatocytes
A Aguilar-Mahecha et al.
BIOLOGY OF REPRODUCTION (2005)
Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectors
T Futami et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Bcl-2 prevents loss of mitochondria in CCCP-induced apoptosis
AO de Graaf et al.
EXPERIMENTAL CELL RESEARCH (2004)
The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly
SC Sampath et al.
CELL (2004)
Carcinogenicity categorization of chemicals - new aspects to be considered in a European perspective
HM Bolt et al.
TOXICOLOGY LETTERS (2004)
Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity
A Lynch et al.
MUTAGENESIS (2003)
Genotoxicity - threshold or not? Introduction of cases of industrial chemicals
HM Bolt
TOXICOLOGY LETTERS (2003)
Detection and characterization of mechanisms of action of aneugenic chemicals
EM Parry et al.
MUTAGENESIS (2002)
Post-translational modifications and activation of p53 by genotoxic stresses
E Appella et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)
Share Paper
