4.7 Article

Dynamic landscape mapping of humoral immunity to SARS-CoV-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Crystal structure of SARS-CoV-2 papain-like protease

Xiaopan Gao et al.

Summary: This study provided structural frameworks for PLpro inhibitor design targeting SARS-CoV-2, showing that existing SARS-CoV PLpro inhibitors have some efficacy against SARS-CoV-2 and explored the inhibition mechanism of GRL0617.

ACTA PHARMACEUTICA SINICA B (2021)

Article Immunology

SARS-CoV-2 Epitope Mapping on Microarrays Highlights Strong Immune-Response to N Protein Region

Angelo Musico et al.

Summary: A workflow for rapid epitope discovery of SARS-CoV-2 on peptide microarrays was reported, leading to the identification of immunodominant regions on the spike, nucleocapsid, and Orf1ab proteins. The epitope of N protein's region 155-171 showed good diagnostic performance in discriminating Covid-19 positive individuals, with 92% sensitivity and 100% specificity for IgG detection. This epitope represents a promising candidate for further development and rapid implementation in serological tests.

VACCINES (2021)

Article Biotechnology & Applied Microbiology

Development of multivalent nanobodies blocking SARS-CoV-2 infection by targeting RBD of spike protein

Qizhong Lu et al.

Summary: This study identified four specific nanobodies with antiviral activity against SARS-CoV-2 spike protein, with the heterodimer nanobody Nb91-Nb3-hFc showing the strongest RBD-binding affinity and neutralizing ability. The use of a naive VHH library could be a potential resource for rapid acquisition of antiviral nanobodies, with Nb91-Nb3-hFc showing potential as a therapeutic agent for COVID-19 treatment.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Biology

Immunoreactive peptide maps of SARS-CoV-2

Nischay Mishra et al.

Summary: Mishra, Huang et al. identified 29 linear SARS-CoV-2 epitopes that are immunoreactive with plasma from individuals who had asymptomatic, mild, or severe SARS-CoV-2 infections. This study suggests the possibility of using these peptides to discriminate the exposure to SARS-CoV-2 and other human coronaviruses.

COMMUNICATIONS BIOLOGY (2021)

Article Immunology

Peptide microarray-based analysis of antibody responses to SARS-CoV-2 identifies unique epitopes with potential for diagnostic test development

Pavlo Holenya et al.

Summary: This study used peptide microarrays to screen for antibodies against various human coronaviruses and found widespread cross-reactivity across several immunodominant regions. Specific SARS-CoV-2-derived peptides were identified as potentially useful for highly COVID-19-specific diagnostic antibody tests.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes

Irwin Jungreis et al.

Summary: Despite the clinical importance, the SARS-CoV-2 gene set remains unresolved, hindering dissection of COVID-19 biology. By comparing 44 Sarbecovirus genomes, a high-confidence protein-coding gene set is provided, characterizing protein-level and nucleotide-level evolutionary constraints, and prioritizing functional mutations from the ongoing COVID-19 pandemic.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

Epitope profiling reveals binding signatures of SARS-CoV-2 immune response in natural infection and cross-reactivity with endemic human CoVs

Caitlin Stoddard et al.

Summary: By developing a pan-coronavirus phage display library, it was found that immune responses to SARS-CoV-2 mainly target the spike protein, nucleocapsid, and ORF1ab, including mutation sites in current variants of concern. There is variability in the number of epitopes targeted between individuals, and low levels of SARS-CoV-2 cross-reactivity were observed in individuals with no exposure to the virus. Additionally, significant cross-reactivity with endemic human coronaviruses was found in convalescent sera from patients with COVID-19.

CELL REPORTS (2021)

Article Immunology

SARS-CoV-2 Proteome-Wide Analysis Revealed Significant Epitope Signatures in COVID-19 Patients

Tatjana Schwarz et al.

Summary: The WHO declared the COVID-19 outbreak as a public health emergency of international concern, with the newly emerged coronavirus, SARS-CoV-2, causing a range of disease outcomes from asymptomatic infection to severe pneumonia. Understanding the host immune response is crucial for intervention strategies, with humoral responses playing a significant role in defending viral infections.

FRONTIERS IN IMMUNOLOGY (2021)

Article Microbiology

Longitudinal Development of Antibody Responses in COVID-19 Patients of Different Severity with ELISA, Peptide, and Glycan Arrays: An Immunological Case Series

Jasmin Heidepriem et al.

Summary: The study analyzed the antibody serum responses of three COVID-19 patients, showing different immune responses among cases. The moderate patient exhibited stronger antibody signal enhancement and epitope spread, while mild cases showed earlier but transient antibody responses.

PATHOGENS (2021)

Review Oncology

The Therapeutic Potential of Nanobodies

Ivana Jovcevska et al.

BIODRUGS (2020)

Editorial Material Medicine, General & Internal

A novel coronavirus outbreak of global health concern

Chen Wang et al.

LANCET (2020)

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

Article Medicine, General & Internal

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

News Item Medicine, General & Internal

China coronavirus: WHO declares international emergency as death toll exceeds 200

Elisabeth Mahase

BMJ-BRITISH MEDICAL JOURNAL (2020)

Article Medicine, General & Internal

Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7)

Pei-Fang Wei

CHINESE MEDICAL JOURNAL (2020)

Review Virology

The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation

Yousef M. O. Alhammad et al.

VIRUSES-BASEL (2020)

Article Multidisciplinary Sciences

Structure of replicating SARS-CoV-2 polymerase

Hauke S. Hillen et al.

NATURE (2020)

Article Multidisciplinary Sciences

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

Zhenming Jin et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Antibody responses to SARS-CoV-2 in patients with COVID-19

Quan-Xin Long et al.

NATURE MEDICINE (2020)

Article Pharmacology & Pharmacy

Structural basis of SARS-CoV-2 3CL(pro) and anti-COVID-19 drug discovery from medicinal plants

Muhammad Tahir ul Qamar et al.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2020)

Article Immunology

Distinct Early Serological Signatures Track with SARS-CoV-2 Survival

Caroline Atyeo et al.

IMMUNITY (2020)

Article Chemistry, Multidisciplinary

Crystal structures of SARS-CoV-2 ADP-ribose phosnhatase: from the apo form to ligand complexes

Karolina Michalska et al.

IUCRJ (2020)

Article Multidisciplinary Sciences

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

Donghyuk Shin et al.

NATURE (2020)

Article Multidisciplinary Sciences

SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses

He-wei Jiang et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin

Petra Krafcikova et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

The Anti-ADAMTS-5 Nanobody(R)M6495 Protects Cartilage Degradation Ex Vivo

Anne Sofie Siebuhr et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Correction Biochemistry & Molecular Biology

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 (vol 27, pg 846, 2020)

Jiangdong Huo et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Article Biochemistry & Molecular Biology

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

Katharina Schubert et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Editorial Material Medicine, General & Internal

Virology, transmission, and pathogenesis of SARS-CoV-2

Muge Cevik et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

Article Chemistry, Multidisciplinary

SARS-CoV-2 Proteome Microarray for Mapping COVID-19 Antibody Interactions at Amino Acid Resolution

Hongye Wang et al.

ACS CENTRAL SCIENCE (2020)

Article Immunology

Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent population

Zhigang Yi et al.

EMERGING MICROBES & INFECTIONS (2020)

Letter Biochemistry & Molecular Biology

Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design

Sheng Lin et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Immunology

Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA

Kang Chen et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Medicine, General & Internal

Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura

M. Scully et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Medicine, Research & Experimental

Opportunities and Challenges for Antibodies against Intracellular Antigens

Xiaofeng Yang et al.

THERANOSTICS (2019)

Review Chemistry, Multidisciplinary

Nanobodies: Chemical Functionalization Strategies and Intracellular Applications

Dominik Schumacher et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Article Medicine, Research & Experimental

Delivery of ALX-0171 by inhalation greatly reduces respiratory syncytial virus disease in newborn lambs

Alejandro Larios Mora et al.

Review Pharmacology & Pharmacy

Targeted Intracellular Delivery of Antibodies: The State of the Art

Tatiana A. Slastnikova et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Immunology

Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics

Peter Bannas et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Radiology, Nuclear Medicine & Medical Imaging

Improved Tumor Targeting of Anti-HER2 Nanobody Through N-Succinimidyl 4-Guanidinomethyl-3-Iodobenzoate Radiolabeling

Marek Pruszynski et al.

JOURNAL OF NUCLEAR MEDICINE (2014)

Review Chemistry, Multidisciplinary

Clinical impact of serum proteins on drug delivery

Felix Kratz et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Review Microbiology

The spike protein of SARS-CoV - a target for vaccine and therapeutic development

Lanying Du et al.

NATURE REVIEWS MICROBIOLOGY (2009)

Review Fisheries

Emergence and evolution of functional heavy-chain antibodies in Camelidae

KE Conrath et al.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2003)