Journal
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
Volume 17, Issue 6, Pages 1479-1482Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/jcrt.JCRT_1097_19
Keywords
Anticancer; apoptosis; caspase; colorectal; flavonoid
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Funding
- Istanbul University [53038]
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The study demonstrated the anti-tumor and apoptosis-inducing effects of acacetin on colorectal cancer cell lines, with no lethal effect on healthy lung cells.
Aim: Acacetin is a natural flavone compound, which is found in several plants as Robinia pseudoacacia and is demonstrated to have anticancerogenic activities in many types of cancer (e.g., human nonsmall cell lung cancer, and prostate). Colorectal carcinoma (CRC) is one of the serious health problems and is a complex disease. We intended to find a more effective new candidate for the treatment of colon cancer, and hence, we designed this study to investigate the effects of acacetin on CRC (HT-29, HCT 116) in vitro. Methods:The study was carried out with the methods that determine for apoptosis (WST-1, Caspase 3/BCA, Annexin V). Results:Acacetin showed antitumor and apoptosis-inducing effects in the CRC cell lines. Conclusions: Acacetin was effective on CRC cell lines, besides no lethal effect on healthy lung cells (MRC-5).
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