Journal
JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE
Volume 35, Issue 3, Pages 218-229Publisher
QUINTESSENCE PUBLISHING CO INC
DOI: 10.11607/ofph.2861
Keywords
burning mouth syndrome; etiology; neuropathy; pain disorder
Categories
Ask authors/readers for more resources
The research suggests that burning mouth syndrome may be the result of a combination of peripheral and central neuropathies, with insufficient high-quality studies to definitively determine the etiology. Further research is needed to better understand the pathophysiology of BMS.
Aims: To conduct a systematic review compiling an update on the pathophysiology of burning mouth syndrome (BMS) by reviewing the theories and studies published in the last 5 years that consider BMS a neuropathic disease. Methods: A literature review was carried out in April 2020 on the PubMed database by using the following MeSH terms: (burning mouth OR burning mouth syndrome OR burning mouth pain OR sore mouth OR burning tongue OR oral neuropathic pain OR glossodynia OR stomatopyrosis) AND (etiopathogenesis OR etiopathological factors OR etiology). Results: The research carried out according to the methodology found 19 casecontrol studies (1 of which was in vivo) and 1 RCT. Of the 19 included studies, 8 showed an evidence score of 2-; 8 showed 2+; another 2 showed 2++; and 1 showed 1+. Quality studies on this topic are insufficient and heterogenous. Conclusion: In the pathogenesis of BMS, both peripheral and central neuropathies appear to play a pivotal role. Nevertheless, the balance between them varies from case to case and tends to overlap. BMS does not seem to be a result of direct damage to the somatosensory nervous system, but a dysfunction in it and in the brain network.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available