Journal
CONTEMPORARY CLINICAL DENTISTRY
Volume 12, Issue 3, Pages 235-240Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/ccd.ccd_510_20
Keywords
Chronic periodontitis; gingival crevicular fluid; interleukin-10; interleukin-6; interleukin-8; photodynamic therapy
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The study demonstrated that using PDT as an adjunct to NSPT in the treatment of chronic periodontitis resulted in a significant reduction in bleeding on probing and a decrease in GCF pro-inflammatory cytokine levels.
Background: Numerous studies have assessed the effect of photodynamic therapy (PDT) both as a primary mode of treatment and as an adjunct to scaling and root planing in the treatment of periodontitis. Some results were nondefinitive and, in part, inconsistent with respect to the clinical and biochemical effects. Hence, the aim of this study was to evaluate the effect of PDT as an adjunct to nonsurgical periodontal therapy (NSPT) on the gingival crevicular fluid (GCF) interleukin-6 (IL-6), IL-8, and IL-10 levels in the treatment of chronic periodontitis (CP). Materials and Methods: In 21 patients with CP, two contralateral sites (premolar and molar) were randomly divided into: control sites (treated with NSPT only) and test sites (treated with NSPT + PDT). Clinical parameters including bleeding on probing (BOP), probing pocket depth, clinical attachment level were evaluated at baseline, 1- and 3 months and biochemical parameters of GCF levels of IL-6, IL-8, and IL-10 were evaluated at baseline and 3-month post-therapy through enzyme-linked immunosorbant assay. Results: A greater improvement in BOP score at 1 month (41.10% +/- 3.58%) and 3-months (38.00% +/- 3.62%) posttherapy was found in the test site as compared to control site. Regarding cytokines, test sites exhibited significant reductions in IL-6 (4.29 +/- 0.67 pg/ml) and IL-8 (308.16 +/- 36.04 pg/ml) levels and increase in IL-10 (14.25 +/- 0.83 pg/ml) level at 3 months (P < 0.0001). Conclusion: Additional application of PDT, adjunctive to NSPT, resulted in a significant reduction in BOP score as well as GCF pro-inflammatory cytokine levels along with an increase in anti-inflammatory cytokine levels, compared to NSPT alone.
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