Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model

This study compared monophasic 100 -ms pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was increased to 60, myocardial damage was comparable to that of the monophasic group. HF-EP protocols were associated with attenuated collateral muscle contractions. This study shows that HF-EP is feasible and effective and that pulse frequency has a significant effect on extent of ablation. (J Am Coll Cardiol EP 2021;7:959 & ndash;964) (c) 2021 by the American College of Cardiology Foundation. Superscript/Subscript Available

Automated summary

This study compared the effects of monophasic pulses and high-frequency electroporation (HF-EP) bursts on myocardial damage in an in vivo animal model. Results showed that HF-EP bursts at different frequencies had varying effects on extent of ablation, with 20 bursts at 100 and 150 kHz causing less damage compared to 10 monophasic pulses. This study demonstrates that HF-EP is feasible and effective, and that pulse frequency plays a significant role in the level of myocardial damage.