4.6 Article

FSTL1 promotes growth and metastasis in gastric cancer by activating AKT related pathway and predicts poor survival

Journal

AMERICAN JOURNAL OF CANCER RESEARCH
Volume 11, Issue 3, Pages 712-+

Publisher

E-CENTURY PUBLISHING CORP

Keywords

Gastric cancer; FSTL1; TLR4/CD14; AKT; prognosis

Categories

Funding

  1. Project of the regional diagnosis and treatment centre of the Health Planning Committee [JBZX-201903]
  2. Key Research and Development Program of Science and Technology Department of Zhejiang Province [2018C03022]
  3. National Health and Family Planning Commission Research Fund
  4. Zhejiang Provincial Medical and Health Major Science and Technology Plan Project [KWJ-ZJ-1802]
  5. National Natural Science Foundation of Zhejiang Province [LQ20H160043]
  6. Programs for Science and Technology Development of Henan Province [212102310198]

Ask authors/readers for more resources

The role of Follistatin-like protein 1 (FSTL1) in tumorigenesis and cancer progression is conflicting. Nevertheless, this study shows that FSTL1 is frequently upregulated in primary GC tissues and significantly correlated with the progression and poor prognosis of gastric cancer. FSTL1 contributes to GC proliferation, migration, and invasion by regulating the AKT signaling pathway.
Accumulating evidence on the role of Follistatin-like protein 1 (FSTL1) in tumorigenesis and cancer progression is conflicting. Nevertheless, the underlying mechanisms by which FSTL1 contributes to gastric cancer (GC) remain unknown. This study shows that FSTL1 was frequently upregulated in primary GC tissues and significantly correlated with infiltrating depth, lymph node metastasis, unfavorable tumor stage and poor prognosis of GC. Down or up-regulation of FSTL1 inhibited or increased, respectively, the proliferation by reducing apoptosis, clonogenicity, migration and invasion of GC cells in vitro. Moreover, the higher expression of FSTL1 promoted subcutaneous xenograft tumor growth and lung/liver tumor metastasis in vivo. Furthermore, we demonstrate that FSTL1 is involved in regulation of the AKT signaling through analyzing databases and experimental results. Mechanistic studies showed that FSTL1 promoted proliferation, migration and invasion in GC, at least partially, by activating AKT via regulating TLR4/CD14. In all, this study highlights the role of the FSTL1-TLR4/CD14-AKT axis, which provided novel insights into the mechanism of growth and metastasis in GC for the first time.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available