Journal
2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC)
Volume -, Issue -, Pages 4200-4203Publisher
IEEE
DOI: 10.1109/EMBC46164.2021.9629893
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Funding
- University of Turin
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Iron accumulation in the brain is considered to be central in inducing oxidative stress and neurodegenerative diseases. This study proposed a mathematical model to simulate iron trafficking in the brain, with sensitivity analysis used to identify key parameters affecting the transport of iron across brain barriers.
Iron accumulation in the brain is supposed to play a central role in the induction of oxidative stress and consequently in neurodegeneration. The sensitive balance of iron in the brain is maintained by the brain barriers system, i.e., the blood-brain barrier between the blood and brain interstitial fluid and the blood-cerebrospinal fluid barrier between the blood and cerebrospinal fluid (CSF). In this work, we proposed a three-compartmental mathematical model simulating iron trafficking between blood, CSF, and cerebral space, describing the direction of fluxes based on the structural and functional characteristics of the brain barriers system. Different techniques of sensitivity analysis were used to evaluate the most important parameters, providing an indication for the most relevant biological functions that potentially affect the physiological transport of iron across brain barriers.
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